CAS 20426-12-4|4-Hydroxychalcone

Introduction：Basic information about CAS 20426-12-4|4-Hydroxychalcone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name4-Hydroxychalcone
CAS Number20426-12-4Molecular Weight224.25500
Density/Boiling Point/
Molecular FormulaC15H12O2Melting Point180-184 °C
MSDS/Flash Point/

Names

Name4-hydroxychalcone
SynonymMore Synonyms

4-Hydroxychalcone BiologicalActivity

Description4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
Related CatalogResearch Areas >>Cardiovascular DiseaseResearch Areas >>Inflammation/Immunology
Target

NF-κB[2]

References

[1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33.

[2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.

Chemical & Physical Properties

Melting Point180-184 °C
Molecular FormulaC15H12O2
Molecular Weight224.25500
Exact Mass224.08400
PSA37.30000
LogP3.28830

Safety Information

Hazard CodesXi
Risk PhrasesR36/37/38:Irritating to eyes, respiratory system and skin .
Safety PhrasesS37/39-S26
RIDADR3077.0
RTECSUD1675000
Hazard Class9.0
HS Code2914501900

Customs

HS Code2914501900
Summary2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Synonyms

4-HYDROXYBENZYLIDENEACETOPHENONE
2-(4-Hydroxybenzylidene)acetophenone
2-(4-Hydroxybenzal)acetophenone
4-HYDROXYCHALCONE
MFCD00016488
HYDROXYCHALCONE,4
BENZYLIDENE-4-HYDROXYACETOPHENONE
CAS 640292-04-2|5-(4-BROMOPHENYL)ISOXAZOLE-3-CARBALDEHYDE
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