Introduction：Basic information about CAS 146062-44-4|Hydroxy Pioglitazone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydroxy Pioglitazone |
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| CAS Number | 146062-44-4 | Molecular Weight | 372.438 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 627.6±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H20N2O4S | Melting Point | 157-158ºC |
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| MSDS | / | Flash Point | 333.4±31.5 °C |
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Names
| Name | Hydroxy Pioglitazone |
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| Synonym | More Synonyms |
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Hydroxy Pioglitazone BiologicalActivity
| Description | Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM，induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM[1]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>PPARResearch Areas >>Metabolic Disease |
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| Target | Ki: 1.2 μM (PPARγ LBD); EC: 680 nM (PPARγ LBD) (Leriglitazone)[1] |
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| References | [1]. Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. J Med Chem. 2019 Feb 28;62(4):2008-2023. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 627.6±55.0 °C at 760 mmHg |
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| Melting Point | 157-158ºC |
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| Molecular Formula | C19H20N2O4S |
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| Molecular Weight | 372.438 |
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| Flash Point | 333.4±31.5 °C |
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| Exact Mass | 372.114380 |
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| PSA | 113.82000 |
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| LogP | 1.11 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.628 |
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| InChIKey | OXVFDZYQLGRLCD-UHFFFAOYSA-N |
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| SMILES | CC(O)c1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 |
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Synonyms
| 5-(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione |
| 5-(4-{2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione |
| 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]- |
| 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
| Pioglitazone Impurity 18 |
