Introduction：Basic information about CAS 122520-86-9|Tyrphostin 47, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tyrphostin 47 |
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| CAS Number | 122520-86-9 | Molecular Weight | 220.248 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 474.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C10H8N2O2S | Melting Point | / |
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| MSDS | / | Flash Point | 240.8±31.5 °C |
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Names
| Name | 3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile |
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| Synonym | More Synonyms |
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Tyrphostin 47 BiologicalActivity
| Description | Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Cell Cycle/DNA Damage >>TopoisomeraseSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR |
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| In Vitro | Tyrphostin AG213 (25 μM, 50 μM, 和 75 μM; 24 h, 48 h, 和 96 h) 增加人脐静脉内皮细胞 (HUVEC) 单层的伤口闭合时间[1]。 Tyrphostin AG213 (100 μM; 1 h) 干扰 HUVEC 焦点粘附和应力纤维形成[1]。 Tyrphostin AG213 (100 μM; 24 h) 抑制 HUVEC 中 pp125FAK 的粘附相关酪氨酸磷酸化[1]。 Tyrphostin AG213 (10 μM; 24 h) 抑制酪氨酸激酶活性，并且呈剂量和时间依赖关系地抑制 HT-29 细胞活力[2]。 |
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| References | [1]. Romer LH, et al. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell. 1994 Mar;5(3):349-61. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 474.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C10H8N2O2S |
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| Molecular Weight | 220.248 |
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| Flash Point | 240.8±31.5 °C |
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| Exact Mass | 220.030655 |
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| PSA | 122.36000 |
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| LogP | 0.93 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.780 |
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| InChIKey | ZGHQGWOETPXKLY-XVNBXDOJSA-N |
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| SMILES | N#CC(=Cc1ccc(O)c(O)c1)C(N)=S |
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| Storage condition | 2-8°C |
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| Water Solubility | DMSO: 50 mg/mL, clear, orange |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| WGK Germany | 3 |
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Synonyms
| 2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- |
| Tyrphostin 47 |
| IN1038 |
| (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenethioamide |
| (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide |
