Introduction：Basic information about CAS 1568-80-5|HIV-1 integrase inhibitor 8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HIV-1 integrase inhibitor 8 |
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| CAS Number | 1568-80-5 | Molecular Weight | 308.41400 |
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| Density | 1.21±0.1 g/cm3(Predicted) | Boiling Point | 478.5℃ at 760 mmHg |
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| Molecular Formula | C21H24O2 | Melting Point | 213-214 °C |
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| MSDS | USA | Flash Point | 220.4℃ |
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Names
| Name | 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol |
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| Synonym | More Synonyms |
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HIV-1 integrase inhibitor 8 BiologicalActivity
| Description | HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>HIV Integrase |
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| In Vitro | HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1]. The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1]. |
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| References | [1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem |
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Chemical & Physical Properties
| Density | 1.21±0.1 g/cm3(Predicted) |
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| Boiling Point | 478.5℃ at 760 mmHg |
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| Melting Point | 213-214 °C |
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| Molecular Formula | C21H24O2 |
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| Molecular Weight | 308.41400 |
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| Flash Point | 220.4℃ |
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| Exact Mass | 308.17800 |
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| PSA | 40.46000 |
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| LogP | 4.74650 |
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| Vapour Pressure | 8.84E-10mmHg at 25°C |
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| InChIKey | SICLLPHPVFCNTJ-UHFFFAOYSA-N |
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| SMILES | CC1(C)CC2(CC(C)(C)c3ccc(O)cc32)c2cc(O)ccc21 |
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Safety Information
Customs
| HS Code | 2906299090 |
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| Summary | 2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi<1H-indene>-6,6'-diol |
| 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobisindane |
| (2,2,3,3-tetrafluoropropoxy)acetic acid |
| 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane |
| 2,2,3,3-Tetrafluor-propyloxy-essigsaeure |
| 3,3,3',3'-tetramethyl-1,1'-spirobisindane-6,6'-diol |
| 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan |
| SPIROBIINDANE |
