CAS 57775-29-8|carazolol

Introduction：Basic information about CAS 57775-29-8|carazolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. carazolol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles31
8. Synonyms

Common Name	carazolol
CAS Number	57775-29-8	Molecular Weight	298.38
Density	1.2±0.1 g/cm3	Boiling Point	531.2±40.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₂N₂O₂	Melting Point	133-137 °C
MSDS	ChineseUSA	Flash Point	275.1±27.3 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	carazolol hcl
Synonym	More Synonyms

carazolol BiologicalActivity

Description	Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
Target	β1 adrenoceptor β2 adrenoceptor β3 adrenoceptor
In Vivo	Carazolol (0.01 mg/kg; i.m.; once) shows no significant side effects[2]. Animal Model: Kivircik sheeps, 25-45 kg, nonpregnant[2] Dosage: 0.01 mg/kg Administration: Intramuscular injection, once Result: Urea, creatinin, ALT, ALP, GGT, LDH, Ca, P, T.Protein, Mg, Cu levels in blood serum parameters were found to be in normal level however serum Fe, Zn levels were decreased.
References	[1]. A Méjean, et al. Carazolol: a potent, selective beta 3-adrenoceptor agonist. Eur J Pharmacol. 1995 Nov 30;291(3):359-66. [2]. Remzi Gonul, et al. Effects of carazolol on electrocadiographic and trace element status in sheeps. Insights Vet Sci. 2018; 2: 001- 004.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	531.2±40.0 °C at 760 mmHg
Melting Point	133-137 °C
Molecular Formula	C₁₈H₂₂N₂O₂
Molecular Weight	298.38
Flash Point	275.1±27.3 °C
Exact Mass	298.168121
PSA	57.28000
LogP	3.59
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.652
InChIKey	BQXQGZPYHWWCEB-UHFFFAOYSA-N
SMILES	CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA8685000

CHEMICAL NAME :: 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((1-methylethyl)amino)-

CAS REGISTRY NUMBER :: 57775-29-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H22-N2-O2

MOLECULAR WEIGHT :: 298.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 10 ug/kg

SEX/DURATION :: female 16 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,191,1983

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S26
RIDADR	NONH for all modes of transport
RTECS	UA8685000
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles31

Determination of 15 sedative residues in mutton by rapid resolution liquid chromatography-tandem mass spectrometry.

J. Sci. Food Agric. 95(3) , 598-606, (2015)

The use of xenobiotic compounds in animal husbandry has given rise to consumer anxieties regarding residual risk and food safety. Thus, animal tissues have become main samples for residue analysis and...

Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.

J. Med. Chem. 52 , 3416-9, (2009)

RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but remains limited for the determination of partition coefficients of moderate to strong basic compounds ...

Constitutive phospholipid scramblase activity of a G protein-coupled receptor.

Nat. Commun. 5 , 5115, (2014)

Opsin, the rhodopsin apoprotein, was recently shown to be an ATP-independent flippase (or scramblase) that equilibrates phospholipids across photoreceptor disc membranes in mammalian retina, a process...

Synonyms

Conduction

1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol

carazolol

CARAZOLOL HYDROCHLORIDE

1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol

EINECS 260-945-1

1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol

suacron

MFCD03428052

2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]-

Carazololum

Conducton

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