Introduction：Basic information about CAS 681281-88-9|Akt Inhibitor IV, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Akt Inhibitor IV |
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| CAS Number | 681281-88-9 | Molecular Weight | 614.54 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C31H27IN4S | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | 6-benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3H-benzoimidazol-1-ium iodide |
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| Synonym | More Synonyms |
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Akt Inhibitor IV BiologicalActivity
| Description | Akt inhibitor-IV (AKTIV) acts as a PI3K-Akt inhibitor at the E isomer (HY-14971), with potent cytotoxicity[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>Akt |
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| References | [1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9. |
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Chemical & Physical Properties
| Molecular Formula | C31H27IN4S |
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| Molecular Weight | 614.54 |
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| Exact Mass | 614.10000 |
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| PSA | 53.18000 |
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| LogP | 8.31990 |
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| InChIKey | NAYRELMNTQSBIN-UHFFFAOYSA-M |
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| SMILES | CC[n+]1c(C=CN(C)c2ccccc2)n(-c2ccccc2)c2ccc(-c3nc4ccccc4s3)cc21.[I-] |
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Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| RIDADR | NONH for all modes of transport |
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Articles2
More Articles
| Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia. J. Thorac. Cardiovasc. Surg. 286 , 9393-404, (2011) Hypoxia promotes neural stem cell proliferation, the mechanism of which is poorly understood. Here, we have identified the nuclear orphan receptor TLX as a mediator for proliferation and pluripotency ... | |
| Akt signaling pathway: a target for radiosensitizing human malignant glioma. Neuro. Oncol. 12 , 434-43, (2010) Radiation therapy plays a central role in the treatment of glioblastoma, but it is not curative due to the high tumor radioresistance. Phosphatidyl-inositol 3-kinase/protein kinase B (Akt) and Janus k... | |
Synonyms
| 5-(2-benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1h-benzimidazolium iodide |
| akt inhibitor iv |
