Introduction：Basic information about CAS 124584-08-3|BNP-32 (human) acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BNP-32 (human) acetate salt |
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| CAS Number | 124584-08-3 | Molecular Weight | 3464.037 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C143H244N50O42S4 | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | nesiritide |
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| Synonym | More Synonyms |
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BNP-32 (human) acetate salt BiologicalActivity
| Description | Nesiritide is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Sequence: Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>CancerPeptides |
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| Target | Kd: 7.3 Pm (NPR-A), 13 pM (NPR-C)[1]. |
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| In Vitro | Nesiritide is an agonist of natriuretic peptide receptor (NPR), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively[1]. ProBNP1-108 stimulates guanylyl cyclase-A (GC-A) to near-maximum activities but is 13-fold less potent than Nesiritide (BNP1-32). ProBNP1-108 binds human GC-A 35-fold less tightly than Nesiritide. Neither proBNP1–108 nor Nesiritide activates GC-B. The natriuretic peptide clearance receptor binds proBNP1-108 3-fold less tightly than Nesiritide. The half time for degradation of proBNP1-108 by human kidney membranes is 2.7-fold longer than for Nesiritide, and the time required for complete degradation is 6-fold longer. Nesiritide and proBNP1-108 are best fitted by first- and second-order exponential decay models, respectively[2]. |
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| References | [1]. Koller KJ, et al. Molecular biology of the natriuretic peptides and their receptors. Circulation. 1992 Oct;86(4):1081-8. [2]. Dickey DM, et al. ProBNP(1-108) is resistant to degradation and activates guanylyl cyclase-A with reduced potency. Clin Chem. 2011 Sep;57(9):1272-8. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C143H244N50O42S4 |
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| Molecular Weight | 3464.037 |
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| Exact Mass | 3461.737793 |
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| PSA | 1613.94000 |
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| LogP | -16.34 |
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| Index of Refraction | 1.679 |
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| Storage condition | -20°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Articles1
More Articles
| Different Susceptibility of B-Type Natriuretic Peptide (BNP) and BNP Precursor (proBNP) to Cleavage by Neprilysin: The N-Terminal Part Does Matter. Clin. Chem. 62 , 617-22, (2016) Protease neprilysin is known to be responsible for the degradation of natriuretic peptides. A recent heart failure (HF) drug, LCZ696 (Entresto(TM)), that combines a neprilysin inhibitor and an angiote... | |
Synonyms
| Nesiritide |
| NESIRITIDE ACETATE |
| RS 45041-190 hydrochloride |
