CAS 86831-54-1|Rhodiosin
Introduction：Basic information about CAS 86831-54-1|Rhodiosin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rhodiosin | ||
|---|---|---|---|
| CAS Number | 86831-54-1 | Molecular Weight | 610.518 |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 994.3±65.0 °C at 760 mmHg |
| Molecular Formula | C27H30O16 | Melting Point | / |
| MSDS | / | Flash Point | 329.1±27.8 °C |
Names
| Name | herbacetin 7-O-(3''-O-β-D-glucopyranosyl-α-L-rhamnopyranoside) |
|---|---|
| Synonym | More Synonyms |
Rhodiosin BiologicalActivity
| Description | Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM[1]. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL[2]. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC50 of 27.77 μM[3]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
| Target | IC50: 0.420 μM (cytochrome P450 2D6)[1]；57.50-2.43 μg/mL (AChE)[2]；27.77 μM (DPPH free radical scavenging)[3] |
| References | [1]. Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea. Pharmazie. 2013 Dec;68(12):974-6. [2]. Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532. [3]. Choe KI, et al. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR. Molecules. 2012 Sep 27;17(10):11484-94. |
Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 994.3±65.0 °C at 760 mmHg |
| Molecular Formula | C27H30O16 |
| Molecular Weight | 610.518 |
| Flash Point | 329.1±27.8 °C |
| Exact Mass | 610.153381 |
| PSA | 269.43000 |
| LogP | -2.25 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.765 |
| InChIKey | WXBBQBYCUTXTJQ-ULMXTSOFSA-N |
| SMILES | CC1OC(Oc2cc(O)c3c(=O)c(O)c(-c4ccc(O)cc4)oc3c2O)C(O)C(OC2OC(CO)C(O)C(O)C2O)C1O |
Synonyms
| herbacetin 7-O-(3'-O-β-D-glucopyranosyl-α-L-rhamnopyranoside) |
| 3,5,8-Trihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 6-deoxy-3-O-β-D-glucopyranosyl-α-L-mannopyranoside |
| Herbacetin-7-O-glucorhamnoside |
| 4H-1-BENZOPYRAN-4-ONE,7-[(6-DEOXY-3-O-B-D-GLUCOPYRANOSYL-A-L-MANNOPYRANOSYL)OXY]-3,5,8-TRIHYDROXY-2-(4-HYDROXYPHENYL)- |
| 4H-1-Benzopyran-4-one, 7-[(6-deoxy-3-O-β-D-glucopyranosyl-α-L-mannopyranosyl)oxy]-3,5,8-trihydroxy-2-(4-hydroxyphenyl)- |
| Rhodiosin |
