CAS 112246-15-8|20(R)-Ginsenoside Rh2

Introduction：Basic information about CAS 112246-15-8|20(R)-Ginsenoside Rh2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 20(R)-Ginsenoside Rh2 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	20(R)-Ginsenoside Rh2
CAS Number	112246-15-8	Molecular Weight	622.873
Density	1.19	Boiling Point	726.4±60.0 °C at 760 mmHg
Molecular Formula	C₃₆H₆₂O₈	Melting Point	225 °C
MSDS	/	Flash Point	393.1±32.9 °C

Names

Name	ginsenoside Rh2
Synonym	More Synonyms

20(R)-Ginsenoside Rh2 BiologicalActivity

Description	20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>MMP
References	[1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6. [2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40. [3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8.

Description

20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>MMP

References

[1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6.

[2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40.

[3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8.

Chemical & Physical Properties

Density	1.19
Boiling Point	726.4±60.0 °C at 760 mmHg
Melting Point	225 °C
Molecular Formula	C₃₆H₆₂O₈
Molecular Weight	622.873
Flash Point	393.1±32.9 °C
Exact Mass	622.444458
PSA	139.84000
LogP	5.62
Vapour Pressure	0.0±5.4 mmHg at 25°C
Index of Refraction	1.572
InChIKey	CKUVNOCSBYYHIS-FJSBSAJOSA-N
SMILES	CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC1C3(C)CCC(OC4OC(CO)C(O)C(O)C4O)C(C)(C)C3CCC12C

Synonyms

(3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl β-D-glucopyranoside

20(R)-Ginsenoside Rh2

20(R)-Ginsenoside-Rh2

b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl

Ginsenoside-Rh2

(R) Ginsenoside Rh2

(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside

20-(R)-Ginsenoside Rh2

β-D-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl

20(R)-GINSENOSIDERH2

Ginsenoside Rh2, 20(R)-

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