Introduction：Basic information about CAS 125971-95-1|Atorvastatin Acetonide tert-Butyl Ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Atorvastatin Acetonide tert-Butyl Ester |
|---|
| CAS Number | 125971-95-1 | Molecular Weight | 654.810 |
|---|
| Density | 1.1±0.1 g/cm3 | Boiling Point | 678.0±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C40H47FN2O5 | Melting Point | 144-148ºC |
|---|
| MSDS | USA | Flash Point | 363.9±31.5 °C |
|---|
Names
| Name | tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
|---|
| Synonym | More Synonyms |
|---|
Atorvastatin Acetonide tert-Butyl Ester BiologicalActivity
| Description | Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids[1]. |
|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
|---|
| References | [1]. Process for preparing amorphous (4r-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid. WO2005063741A1. |
|---|
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|
| Boiling Point | 678.0±55.0 °C at 760 mmHg |
|---|
| Melting Point | 144-148ºC |
|---|
| Molecular Formula | C40H47FN2O5 |
|---|
| Molecular Weight | 654.810 |
|---|
| Flash Point | 363.9±31.5 °C |
|---|
| Exact Mass | 654.346924 |
|---|
| PSA | 78.79000 |
|---|
| LogP | 7.78 |
|---|
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
|---|
| Index of Refraction | 1.569 |
|---|
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 3 |
|---|
Synonyms
| tert-butyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin Acetonide tert-Butyl Ester |
| MFCD08458280 |
| T6O COTJ B1 B1 D1VOX1&1&1 F2- AT5NJ BY1&1 CVMR& DR ER DF &&(4R,6R)- Form |
| Atorvastatin intermediate L1 |
| tert-Butyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- |
| 2-Methyl-2-propanyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin calciuM interMediate |
| (4R-CIS)-[1,1-DIMETHYLETHYL-6-[(2-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE |
| Atorvastatin Impurity 30 |
