CAS 2634-33-5|Benzisothiazolone
Introduction：Basic information about CAS 2634-33-5|Benzisothiazolone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benzisothiazolone | ||
|---|---|---|---|
| CAS Number | 2634-33-5 | Molecular Weight | 151.19 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 204.5±23.0 °C at 760 mmHg |
| Molecular Formula | C7H5NOS | Melting Point | 154-158ºC |
| MSDS | ChineseUSA | Flash Point | 77.5±22.6 °C |
| Symbol | GHS05, GHS07, GHS09 | Signal Word | Danger |
Names
| Name | benzo[d]isothiazol-3-one |
|---|---|
| Synonym | More Synonyms |
Benzisothiazolone BiologicalActivity
| Description | Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model [1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
| References | [1]. CollierPJ, et al. Growth inhibitory and biocidal activity of some isothiazolonebiocides. J Appl Bacteriol. 1990 Oct;69(4):569-77. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 204.5±23.0 °C at 760 mmHg |
| Melting Point | 154-158ºC |
| Molecular Formula | C7H5NOS |
| Molecular Weight | 151.19 |
| Flash Point | 77.5±22.6 °C |
| Exact Mass | 151.009186 |
| PSA | 61.10000 |
| LogP | 1.78 |
| Vapour Pressure | 0.2±0.4 mmHg at 25°C |
| Index of Refraction | 1.745 |
| InChIKey | DMSMPAJRVJJAGA-UHFFFAOYSA-N |
| SMILES | O=c1[nH]sc2ccccc12 |
| Water Solubility | Soluble in dichloromethane, dimethyl sulfoxide, methanol. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1020 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9375 No. of Facilities: 4586 (estimated) No. of Industries: 57 No. of Occupations: 57 No. of Employees: 92923 (estimated) No. of Female Employees: 15307 (estimated)
Safety Information
| Symbol | GHS05, GHS07, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H317-H318-H400 |
| Precautionary Statements | P273-P280-P301 + P312 + P330-P305 + P351 + P338 + P310-P333 + P313-P391 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R38;R41;R43;R50 |
| Safety Phrases | S24-S26-S37/39-S61 |
| RIDADR | UN 3077 |
| WGK Germany | 2 |
| RTECS | DE4620000 |
| Packaging Group | III |
| HS Code | 2934200090 |
Preparation
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles26
More Articles| Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone. Bioorg. Med. Chem. Lett. 21(24) , 7321-4, (2011) The regulation of 2-arachidonoylglycerol (2-AG) levels is a major issue as 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. Octhilinon... | |
| Solid-phase synthesis of benzisothiazolones as serine protease inhibitors. Bioorg. Med. Chem. Lett. 9(5) , 663-6, (1999) An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been... | |
| A colorimetric assay for high-throughput screening of inhibitors of herpes simplex virus type 1 alkaline nuclease. Anal. Biochem. 293(2) , 239-45, (2001) Herpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alkaline nuclease (AN) because of its elevated pH optimum. Studies with recombinant viruses which cont... |
Synonyms
| Benzisothiazolone |
| 2,3-dihydro-3-oxo-1,2-benzisothiazole |
| benzo[d]isothiazol-3-one |
| Proxan |
| proxel |
| Proxel AB |
| proxil |
| 1,2-Benzothiazol-3-ol |
| EINECS 220-120-9 |
| Benzisothiazolone (BIT) |
| 1,2-benzoisothiazolin-3-one |
| BIOCIDE--BIT |
| Proxel XL |
| MFCD00127753 |
| T56 BSMVJ |
| Benzocil |
| 1,2-benzisothiazol-3-one |
| 1,2-Benzisothiazol-3(2H)-one |
| T56 BSNJ DQ |
| BIT |
| proxelpl |
| 1,2-Benzisothiazolin-3-One |
| 1,2-Benzothiazol-3(2H)-one |
| PROXELHL |
| 1,2-Benzisothiazol-3-ol |
