CAS 113-24-6|Sodium 2-oxopropanoate
| Common Name | Sodium 2-oxopropanoate | ||
|---|---|---|---|
| CAS Number | 113-24-6 | Molecular Weight | 110.04 |
| Density | 1.267g/cm3 | Boiling Point | 165ºC at 760 mmHg |
| Molecular Formula | C3H3NaO3 | Melting Point | >300 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 54.3ºC |
Names
| Name | sodium pyruvate |
|---|---|
| Synonym | More Synonyms |
Sodium 2-oxopropanoate BiologicalActivity
| Description | Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic Disease |
| Target | Microbial Metabolite |
| In Vitro | In the process of scavenging hydrogen peroxide, Sodium 2-oxopropanoate (Sodium pyruvate) is decarboxylated to lactate and hence diverted away from aerobic metabolism and further ROS generation. Under conditions in which pyruvate stimulated JNK1 activity, both mitochondrial and cytosolic ROS levels rose. An increase in JNK1 activity in a variety of different cell types over a range of pyruvate concentrations are observed[1]. Sodium 2-oxopropanoate (Sodium pyruvate) is an effective scavenger of H2O2 as well as of O2▪-, thereby protecting the lens against oxidative stress and consequent cataract formation, under in vitro as well as in vivo conditions, Sodium 2-oxopropanoate has also been shown to protect the lens proteins against glycation by competitively inhibiting the initial reaction between the sugar carbonyl and the protein -NH2[2]. |
| In Vivo | Neonatal rats are given a bolus of Sodium 2-oxopropanoate (Sodium pyruvate; 0.1-10 g/kg), and 1 h later, levels of JNK1 activity were determined in liver extracts. Sodium 2-oxopropanoate (Sodium pyruvate) addition resulted in a significant increase in JNK1 activity. Analysis of serum levels of Sodium 2-oxopropanoate in neonatal rats revealed that baseline levels of pyruvate are 0.30 mM. At the time of sacrifice, following the largest dose of Sodium 2-oxopropanoate, serum levels rose approximately sixfold to 1.84 mM[1]. |
| References | [1]. S Nemoto, et al. Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol. 2000 Oct;20(19):7311-8. [2]. W Zhao, et al. Fructose induced deactivation of antioxidant enzymes: preventive effect of pyruvate. Free Radic Res. 2000 Jul;33(1):23-30. |
Chemical & Physical Properties
| Density | 1.267g/cm3 |
|---|---|
| Boiling Point | 165ºC at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C3H3NaO3 |
| Molecular Weight | 110.04 |
| Flash Point | 54.3ºC |
| Exact Mass | 109.997986 |
| PSA | 57.20000 |
| Vapour Pressure | 0.968mmHg at 25°C |
| Index of Refraction | 1.426-1.43 |
| InChIKey | DAEPDZWVDSPTHF-UHFFFAOYSA-M |
| SMILES | CC(=O)C(=O)[O-].[Na+] |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | H2O: 100 mg/mL |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S37/39-S26-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29183000 |
Customs
| HS Code | 2918300090 |
|---|---|
| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| PYRUVATE |
| PYR NA |
| Pyruvic acid,sodium salt |
| sodium 2-oxopropanoate |
| Sodium pyroracemate |
| p.A.,100g |
| Sodium pyruate |
| SodiuM Pyruvate |
| Pyruvic acid sodium salt |
| pyruvic acid sodium |
| 2-oxopropanoic acid sodium salt |
| sodium salt of pyruvic acid |
| EINECS 204-024-4 |
| SodiuM pyrovaceMate |
| BioChemica,100g |
| MFCD00002586 |
