CAS 2140-46-7|25-Hydroxycholesterol
| Common Name | 25-Hydroxycholesterol | ||
|---|---|---|---|
| CAS Number | 2140-46-7 | Molecular Weight | 402.653 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 513.1±23.0 °C at 760 mmHg |
| Molecular Formula | C27H46O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 213.5±17.2 °C |
| Symbol | GHS07, GHS08 | Signal Word | Warning |
Names
| Name | 25-hydroxycholesterol |
|---|---|
| Synonym | More Synonyms |
25-Hydroxycholesterol BiologicalActivity
| Description | 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologyNatural Products >>Steroids |
| Target | Human Endogenous Metabolite |
| In Vitro | The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1]. |
| References | [1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.1±23.0 °C at 760 mmHg |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.653 |
| Flash Point | 213.5±17.2 °C |
| Exact Mass | 402.349792 |
| PSA | 40.46000 |
| LogP | 7.66 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.538 |
| InChIKey | INBGSXNNRGWLJU-ZHHJOTBYSA-N |
| SMILES | CC(CCCC(C)(C)O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| Storage condition | 2-8℃ |
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H319-H332-H335-H373 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20/21/22-36/37/38-48 |
| Safety Phrases | 26-36-45 |
| RIDADR | NONH for all modes of transport |
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Synonyms
| 25-Hydroxy Cholesterol |
| (3β,9β,14β)-Cholest-5-ene-3,25-diol |
| Cholest-5-ene-3,25-diol, (3β,9β,14β)- |
| (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
