CAS 1264-62-6|Erythromycin Ethylsuccinate
Introduction：Basic information about CAS 1264-62-6|Erythromycin Ethylsuccinate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Erythromycin Ethylsuccinate | ||
|---|---|---|---|
| CAS Number | 1264-62-6 | Molecular Weight | 862.053 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 874.1±65.0 °C at 760 mmHg |
| Molecular Formula | C43H75NO16 | Melting Point | 219-224ºC |
| MSDS | ChineseUSA | Flash Point | 482.4±34.3 °C |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | Erythromycin ethyl succinate |
|---|---|
| Synonym | More Synonyms |
Erythromycin Ethylsuccinate BiologicalActivity
| Description | Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. |
|---|---|
| Related Catalog | Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 874.1±65.0 °C at 760 mmHg |
| Melting Point | 219-224ºC |
| Molecular Formula | C43H75NO16 |
| Molecular Weight | 862.053 |
| Flash Point | 482.4±34.3 °C |
| Exact Mass | 861.508606 |
| PSA | 226.28000 |
| LogP | 4.10 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.529 |
| InChIKey | NSYZCCDSJNWWJL-NLATUGTHSA-N |
| SMILES | CCOC(=O)CCC(=O)OC1C(OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)OC(C)CC1N(C)C |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: soluble50mg/mL | Freely soluble in organic solvents, practically insoluble in water |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 420 mg/kg/7D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Liver - other changes
- REFERENCE :
- CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 129,411,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 5714 ug/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 10,616,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4167 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,445,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,126,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0949 No. of Facilities: 113 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3065 (estimated) No. of Female Employees: 1433 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P284-P304 + P340-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R42/43 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | WM9800000 |
| HS Code | 2941500000 |
Customs
| HS Code | 2941500000 |
|---|
Articles30
More Articles| Hapten synthesis, monoclonal antibody production and development of a competitive indirect enzyme-linked immunosorbent assay for erythromycin in milk. Food Chem. 171 , 98-107, (2014) Erythromycin is an antibiotic used extensively in veterinary practice worldwide for treatment, prevention and growth promotion. In this work, monoclonal antibodies (Mabs) against erythromycin were pro... | |
| Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications. J. Sep. Sci. 33(9) , 1305-11, (2010) A sensitive approach for the simultaneous determination of tilmicosin, erythromycin ethylsuccinate and clindamycin was developed by CE coupled with electrochemiluminescence detection with ionic liquid... | |
| Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs. J. Vet. Pharmacol. Ther. 31(6) , 496-500, (2008) The purpose of this study was to describe and compare the pharmacokinetic properties of different formulations of erythromycin in dogs. Erythromycin was administered as lactobionate (10 mg/kg, IV), es... |
Synonyms
| ERYTHROMYCIN ETHYISUCCINATE |
| ERYTHROCINETHYLSUCCINATE |
| ErythromycinEthylsuccinate |
| Erythromycin ethylsuccinate |
| ERYTHROMYCIN ETHYL SUCCINATE |
| ERYTHROMYCIN ETHYLSUCCINATE API |
| (2S,3R,4S,6R)-4-(Dimethylamino)-2-{[(3S,4R,5R,6S,7S,9S,11S,12S,13R,14S)-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecan-6-yl]oxy}-6-methyltetrahydro-2H-pyran-3-yl ethyl succinate |
| ERYTHROMYCIN ETHYLSUCCINATE, ANTIBIOTIC FOR CULTURE MEDIA USE ONLY |
