CAS 124858-35-1|Nadifloxacin

Introduction：Basic information about CAS 124858-35-1|Nadifloxacin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nadifloxacin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles3
6. Synonyms

Common Name	Nadifloxacin
CAS Number	124858-35-1	Molecular Weight	360.379
Density	1.5±0.1 g/cm3	Boiling Point	624.9±55.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₁FN₂O₄	Melting Point	245-247ºC (dec)
MSDS	ChineseUSA	Flash Point	331.7±31.5 °C

Names

Name	nadifloxacin
Synonym	More Synonyms

Nadifloxacin BiologicalActivity

Description	Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. Target: AntibacterialNadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis [1, 2].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Inflammation/Immunology
References	[1]. Jacobs, M.R. and P.C. Appelbaum, Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771. Expert Opin Pharmacother, 2006. 7(14): p. 1957-66. [2]. Choudhury, S., et al., Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Indian J Pharmacol, 2011. 43(6): p. 628-31.

Description

Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. Target: AntibacterialNadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis [1, 2].

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Inflammation/Immunology

References

[1]. Jacobs, M.R. and P.C. Appelbaum, Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771. Expert Opin Pharmacother, 2006. 7(14): p. 1957-66.

[2]. Choudhury, S., et al., Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Indian J Pharmacol, 2011. 43(6): p. 628-31.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	624.9±55.0 °C at 760 mmHg
Melting Point	245-247ºC (dec)
Molecular Formula	C₁₉H₂₁FN₂O₄
Molecular Weight	360.379
Flash Point	331.7±31.5 °C
Exact Mass	360.148529
PSA	82.77000
LogP	1.95
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.669
InChIKey	JYJTVFIEFKZWCJ-UHFFFAOYSA-N
SMILES	CC1CCc2c(N3CCC(O)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
Storage condition	-20?C Freezer

Safety Information

RIDADR	NONH for all modes of transport

Articles3

Efficacy and safety of nadifloxacin for bacterial skin infections: results from clinical and post-marketing studies.

Dermatol. Ther. (Heidelb.) 4(2) , 233-48, (2014)

Skin and soft tissue infections involve microbial invasion of the skin and underlying soft tissues and are estimated to affect 7-10% of hospitalized patients worldwide. Nadifloxacin, a topical fluoroq...

Green Nail Syndrome (Pseudomonas aeruginosa Nail Infection): Two Cases Successfully Treated with Topical Nadifloxacin, an Acne Medication.

Case Rep. Dermatol. 6(2) , 180-4, (2014)

Green nail syndrome (GNS) caused by Pseudomonas aeruginosa is the most common bacterial nail infection. The treatment of GNS is challenging in many cases and recommendations based on clinical trials a...

Design and evaluation of microemulsion gel system of nadifloxacin.

Indian J. Pharm. Sci. 74(3) , 237-47, (2012)

Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubil...

Synonyms

9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid

(±)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic Acid

Nadiflox

Activon

1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-

Acuatim

Jinofloxacin

Nadifloxacin

9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid

Nadixa

Nadoxin

MFCD00865081

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