CAS 4238-71-5|1-benzylimidazole
| Common Name | 1-benzylimidazole | ||
|---|---|---|---|
| CAS Number | 4238-71-5 | Molecular Weight | 158.20 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 310.0±11.0 °C at 760 mmHg |
| Molecular Formula | C10H10N2 | Melting Point | 68-70 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 141.3±19.3 °C |
Names
| Name | 1-Benzylimidazole |
|---|---|
| Synonym | More Synonyms |
1-benzylimidazole BiologicalActivity
| Description | 1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
|---|---|
| Related Catalog | Research Areas >>Others |
| In Vitro | Benzylimidazole 是一种选择性血栓素合成酶抑制剂和 UDP-葡萄糖醛基转移酶刺激剂。血栓素合成酶是一种细胞色素 P450 酶。细胞色素 P450 蛋白参与催化药物代谢和胆固醇、类固醇和其他脂类合成的许多反应。该酶在一些病理生理过程中起重要作用，包括止血、心血管疾病和中风。该基因表达两种转录变体。1-苯并咪唑选择性抑制血栓博烷合成酶活性。1-苯并咪唑降低大鼠脑缺血再灌注损伤后 TXB2 水平，增加血流量。雄性 Wistar 大鼠经胃给予 1-苯并咪唑 (25、75和100 mg/kg/天) 可引起剂量依赖性肝炎。1-苯并咪唑降低血浆甘油三酯水平 60-70%。1-苯并咪唑刺激三种不同形式的 UDP-葡萄糖醛基转移酶。1-苯并咪唑对 4-甲基菊酮、1-萘酚、吗啡和一种单萜类醇 nopol 的活性显著提高。苯并咪唑呈浓度依赖性增加肝细胞 CYP1A 催化活性和 CYP1A mRNA。 |
| References | [1]. Pettigrew LC, Grotta JC, Rhoades HM, et al. Effect of thromboxane synthase inhibition on eicosanoid levels and blood flow in ischemic rat brain[J]. Stroke, 1989, 20(5): 627-632 [2]. Magdalou J, Totis M, Boiteux-Antoine AF, et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxy hydrolases and UDP-glucuronosyltransferases in rat liver[J]. Biochemical pharmacology, 1988, 37(17): 3297-330 Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science , 1998, 5(3): 153-17 [3]. Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-17 [4]. Navas JM, Chana A, Herradón B, et al. Induction of CYP1A by the N‐imidazole derivative, 1‐benzylimidazole[J]. Environmental toxicity and chemistry, 2003, 22(4): 830-83 |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 310.0±11.0 °C at 760 mmHg |
| Melting Point | 68-70 °C(lit.) |
| Molecular Formula | C10H10N2 |
| Molecular Weight | 158.20 |
| Flash Point | 141.3±19.3 °C |
| Exact Mass | 158.084396 |
| PSA | 17.82000 |
| LogP | 1.46 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.580 |
| InChIKey | KKKDZZRICRFGSD-UHFFFAOYSA-N |
| SMILES | c1ccc(Cn2ccnc2)cc1 |
| Water Solubility | insoluble |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933290090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles38
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Synonyms
| 1-BENZYL IMIDAZOLE |
| MFCD00005296 |
| Imidazole,1-benzyl |
| 1H-Imidazole, 1-(phenylmethyl)- |
| 1-benzylimidazole |
| 1H-Imidazole, 1- (phenylmethyl)- |
| BENZYLIMIDAZOLE |
| 1-Benzyl-1H-imidazole |
| N-benzylimidazole |
| EINECS 224-200-4 |
| 3-Benzylimidazole |
