CAS 140-31-8|2-Piperazinoethylamine

Introduction：Basic information about CAS 140-31-8|2-Piperazinoethylamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles20
7. Synonyms

Common Name	2-Piperazinoethylamine
CAS Number	140-31-8	Molecular Weight	129.203
Density	1.0±0.1 g/cm3	Boiling Point	220.0±8.0 °C at 760 mmHg
Molecular Formula	C₆H₁₅N₃	Melting Point	-19 °C
MSDS	ChineseUSA	Flash Point	93.3±0.0 °C
Symbol	GHS05, GHS06	Signal Word	Danger

Names

Name	N-Aminoethylpiperazine
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	220.0±8.0 °C at 760 mmHg
Melting Point	-19 °C
Molecular Formula	C₆H₁₅N₃
Molecular Weight	129.203
Flash Point	93.3±0.0 °C
Exact Mass	129.126602
PSA	41.29000
LogP	-0.86
Vapour density	4.4 (vs air)
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.479
InChIKey	IMUDHTPIFIBORV-UHFFFAOYSA-N
SMILES	NCCN1CCNCC1
Stability	Stable. Flammable. Incompatible with acids, acid anhydrides, acid chlorides, strong oxidizing agents, chloroformates.
Water Solubility	soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK8050000

CHEMICAL NAME :: Piperazine, 1-(2-aminoethyl)-

CAS REGISTRY NUMBER :: 140-31-8

BEILSTEIN REFERENCE NO. :: 0104363

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H15-N3

MOLECULAR WEIGHT :: 129.24

WISWESSER LINE NOTATION :: T6M DNTJ D2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2140 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 880 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1680 mg/kg

SEX/DURATION :: male 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,31,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1937 No. of Facilities: 328 (estimated) No. of Industries: 11 No. of Occupations: 17 No. of Employees: 11542 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1937 No. of Facilities: 4514 (estimated) No. of Industries: 42 No. of Occupations: 41 No. of Employees: 60625 (estimated) No. of Female Employees: 12978 (estimated)

Safety Information

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H302-H311-H314-H317-H412
Precautionary Statements	P273-P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C:Corrosive;
Risk Phrases	R21/22;R34;R43;R52/53
Safety Phrases	S26-S36/37/39-S45-S61
RIDADR	UN 2815 8/PG 3
WGK Germany	2
RTECS	TK8050000
Packaging Group	III
Hazard Class	8
HS Code	2933599090

Customs

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles20

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Bioorg. Med. Chem. 16 , 3530-6, (2008)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

Bioorg. Med. Chem. Lett. 16 , 3955-9, (2006)

The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine ...

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

Bioorg. Med. Chem. 15 , 5351-7, (2007)

The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration r...

Synonyms

2-piperazin-1-ylethanamine

2-Piperazinoethylamine

1-(2-Aminoethyl)piperazine

N-(2-Aminoethyl)piperazin

N-(2-Aminoethyl)piperazine

2-(1-Piperazinyl)ethanamine

Piperazine, 1- (2-aminoethyl)-

N-(β-Aminoethyl)piperazine

1-(2-aminoethyl) piperazine

2-(piperazin-1-yl)ethanamine

EINECS 205-411-0

1-Piperazineethanamine

MFCD00005971

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