CAS 67-97-0|Vitamin D3

Introduction：Basic information about CAS 67-97-0|Vitamin D3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Vitamin D3 BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles228
8. Synonyms

Common Name	Vitamin D3
CAS Number	67-97-0	Molecular Weight	384.638
Density	1.0±0.1 g/cm3	Boiling Point	496.4±24.0 °C at 760 mmHg
Molecular Formula	C₂₇H₄₄O	Melting Point	83-86 °C(lit.)
MSDS	ChineseUSA	Flash Point	214.2±15.1 °C
Symbol	GHS06, GHS08	Signal Word	Danger

Names

Name	calciol
Synonym	More Synonyms

Vitamin D3 BiologicalActivity

Description	Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. IC50 value:Target: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
Related Catalog	Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>CancerNatural Products >>Others
Target	Human Endogenous Metabolite
References	[1]. Leibowitz SB, Kantoff PW. Differentiating agents and the treatment of prostate cancer: Vitamin D3 and peroxisome proliferator-activated receptor gamma ligands. Semin Oncol. 2003 Oct;30(5):698-708. [2]. Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology. 2011 Oct;134(2):123-39. doi: 10.1111/j.1365-2567.2011.03482.x. [3]. Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311-36. doi: 10.1146/annurev-pharmtox-010510-100611. [4]. Nigwekar SU, Bhan I, Thadhani R. Ergocalciferol and cholecalciferol in CKD. Am J Kidney Dis. 2012 Jul;60(1):139-56. doi: 10.1053/j.ajkd.2011.12.035.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	496.4±24.0 °C at 760 mmHg
Melting Point	83-86 °C(lit.)
Molecular Formula	C₂₇H₄₄O
Molecular Weight	384.638
Flash Point	214.2±15.1 °C
Exact Mass	384.339203
PSA	20.23000
LogP	9.72
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.523
Storage condition	2~8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VS2900000

CHEMICAL NAME :: 9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol

CAS REGISTRY NUMBER :: 67-97-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C27-H44-O

MOLECULAR WEIGHT :: 384.71

WISWESSER LINE NOTATION :: L56 FYTJ A1 BY1&3Y1&1 FU2U- BL6YYTJ AU1 DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 39 mg/kg/34W-I

TOXIC EFFECTS :: Behavioral - anorexia (human) Behavioral - irritability Gastrointestinal - decreased motility or constipation

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 295,1173,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 43,125,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 43(255-256),14,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,105,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Gastrointestinal - other changes

REFERENCE :: JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 193,211,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 90 mg/kg

SEX/DURATION :: female 12-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland) V.1- 1929- Volume(issue)/page/year: 29,333,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80574 No. of Facilities: 179 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 6614 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80574 No. of Facilities: 2284 (estimated) No. of Industries: 12 No. of Occupations: 36 No. of Employees: 85071 (estimated) No. of Female Employees: 59178 (estimated)

Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301 + H311-H330-H372
Precautionary Statements	P260-P280-P284-P301 + P310-P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+:Verytoxic;
Risk Phrases	R24/25;R26;R48/25
Safety Phrases	S28-S36/37-S45-S28A
RIDADR	UN 2811 6.1/PG 2
WGK Germany	2
RTECS	VS2900000
Packaging Group	II
Hazard Class	6.1
HS Code	2936240000

Customs

HS Code	2936240000

Articles228

Effect of concentrate feeder design on performance, eating and animal behavior, welfare, ruminal health, and carcass quality in Holstein bulls fed high-concentrate diets.

J. Anim. Sci. 93 , 3018-33, (2015)

A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Synonyms

Oxarol

Vitamin D3

Ebivit

Cholecalciferolum

(3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-ol

(1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5-Dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yliden}ethyliden]-4-methylidencyclohexanol

Cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)-

Micro-Dee

(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol

Deparal

FeraCol

MFCD00078131

9,10-secocholesta-5,7,10-trien-3-ol, (3S,5Z,7E)-

Prezios

cholecalciferol

(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylenecyclohexanol

UNII-1C6V77QF41

Vi-De3

MC 1275

Granuvit D3

Devaron

(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-(1,5-dimethylhexyl)octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)-

rampage

vitamin D3 powder

D3-Vicotrat

NEO Dohyfral D3

(1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexanol

Vigantol

EINECS 200-673-2

9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3β,5Z,7E)-

(1S,3Z)-4-Methylene-3-[(2E)-2-{(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-2-heptanyl]octahydro-4H-inden-4-ylidene}ethylidene]cyclohexanol

colecalciferol

Videkhol

(3β,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

[3H]-Vitamin D3

9,10-Secocholesta-5,7,10(19)-trien-3b-ol

calciol

Provitina

VITAMIN D

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