CAS 125-02-0|Prednisolone Sodium Phosphate

Introduction：Basic information about CAS 125-02-0|Prednisolone Sodium Phosphate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Prednisolone Sodium Phosphate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Prednisolone Sodium Phosphate
CAS Number	125-02-0	Molecular Weight	484.388
Density	/	Boiling Point	100 °C
Molecular Formula	C₂₁H₂₇Na₂O₈P	Melting Point	/
MSDS	/	Flash Point	361.9ºC

Names

Name	Prednisolone phosphate sodium
Synonym	More Synonyms

Prednisolone Sodium Phosphate BiologicalActivity

Description	Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Glucocorticoid ReceptorResearch Areas >>Inflammation/Immunology
References	[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95. [2]. http://en.wikipedia.org/wiki/Prednisolone

Description

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Glucocorticoid ReceptorResearch Areas >>Inflammation/Immunology

References

[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95.

[2]. http://en.wikipedia.org/wiki/Prednisolone

Chemical & Physical Properties

Boiling Point	100 °C
Molecular Formula	C₂₁H₂₇Na₂O₈P
Molecular Weight	484.388
Flash Point	361.9ºC
Exact Mass	484.123901
PSA	156.83000
LogP	2.55100
Vapour Pressure	4.17E-21mmHg at 25°C
InChIKey	VJZLQIPZNBPASX-OJJGEMKLSA-L
SMILES	CC12C=CC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4153300

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt

CAS REGISTRY NUMBER :: 125-02-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H27-O8-P.2Na

MOLECULAR WEIGHT :: 484.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,1439,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5598 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

Safety Information

Hazard Codes	Xi
Risk Phrases	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
HS Code	2937229000

Customs

HS Code	2937229000

Synonyms

(11beta)

Phortisolone

disodium 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl phosphate

Inflamase

prednisolon disodium phosphate

Prednisolone sodium phosphate

Optival

Predsol

Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)-

11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Disodium phosphate)

Codelsol

Prednisolone (disodium phosphate)

prednisolone 21-disodium phosphate

Prednisolone 21-Phosphate Disodium Salt

MFCD07776968

11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate)

phosphate de 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-diméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle de disodium

METRETON

Prozorin

Disodium Prednisolone 21-Phosphate

EINECS 204-722-9

Solucort

Dinatrium-2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylphosphat

Predsolan

Prednesol

Dojilon

Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, sodium salt, (11β)- (1:2)

Disodium (11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate

Ak-pred

Recommended......