CAS 54048-10-1|Etonogestrel

Introduction：Basic information about CAS 54048-10-1|Etonogestrel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Articles38
6. Synonyms

Common Name	Etonogestrel
CAS Number	54048-10-1	Molecular Weight	324.457
Density	1.1±0.1 g/cm3	Boiling Point	473.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₈O₂	Melting Point	182-184ºC
MSDS	ChineseUSA	Flash Point	201.1±21.3 °C
Symbol	GHS08	Signal Word	Danger

Names

Name	etonogestrel
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	473.1±45.0 °C at 760 mmHg
Melting Point	182-184ºC
Molecular Formula	C₂₂H₂₈O₂
Molecular Weight	324.457
Flash Point	201.1±21.3 °C
Exact Mass	324.208923
PSA	37.30000
LogP	4.22
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.575
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JF8290000

CHEMICAL NAME :: 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)-

CAS REGISTRY NUMBER :: 54048-10-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H28-O2

MOLECULAR WEIGHT :: 324.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10500 ng/kg

SEX/DURATION :: female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 17,19,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 50 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,459,1985

Safety Information

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H351-H360
Precautionary Statements	P201-P280-P308 + P313
Hazard Codes	Xn
Risk Phrases	60-40
RIDADR	NONH for all modes of transport
RTECS	JF8290000

Articles38

Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs.

Contraception 90(2) , 123-9, (2014)

The potential effect of hormonal contraception on HIV-1 acquisition and transmission represents an important public health issue. Several observational studies have suggested an association between th...

Newer non-oral hormonal contraception.

BMJ 346 , f341, (2013)

The combined etonogestrel/ethinyl estradiol contraceptive vaginal ring.

Expert Opin. Pharmacother. 8(11) , 1769-77, (2007)

Many factors influence the effectiveness of contraceptive methods. Oral contraceptives are the second most popular contraceptive method after female sterilization in the US. A total of 25% of women do...

Synonyms

EINECS 258-936-2

3-Ketodesogestrel,3-Oxodesogestrel,Org-3236,Implanon

Etonoestrel

3-Keto-desogestrel 3-Oxo-desogestrel

(17a)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one

3-Oxodesogestrel

3-Keto-Org 2969

18,19-Dinor-17α-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-

3-keto-desogestrel

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

13-Ethyl-17-hydroxy-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3-one

3-Ketodesogestrel

Etonogestrel

Nexplanon

Desogestrel Related Compound C (25 mg) (3-Keto-desogestrel)

(8S,9S,10R,13S,14S,17R)-17-Ethinyl-13-ethyl-17-hydroxy-11-methyliden-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-on

UNII-304GTH6RNH

MFCD00867863

Implanon

[3H]-3-keto-Desogestrel

org3236

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)

17-Ethinyl-17b-hydroxy-18-methyl-11-methylene-4-estren-3-one

(8S,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-11-methylene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

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