CAS 156-39-8|4-Hydroxyphenylpyruvic acid
Introduction：Basic information about CAS 156-39-8|4-Hydroxyphenylpyruvic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Hydroxyphenylpyruvic acid | ||
|---|---|---|---|
| CAS Number | 156-39-8 | Molecular Weight | 180.15700 |
| Density | 1.397 g/cm3 | Boiling Point | 380.8ºC at 760 mmHg |
| Molecular Formula | C9H8O4 | Melting Point | 219-220 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 198.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (4-hydroxyphenyl)pyruvic acid |
|---|---|
| Synonym | More Synonyms |
4-Hydroxyphenylpyruvic acid BiologicalActivity
| Description | 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| References | [1]. Brand LM, et al. Effect of glucagon on phenylalanine metabolism and phenylalanine-degrading enzymes in the rat. Biochem J. 1974 Aug;142(2):231-45. |
Chemical & Physical Properties
| Density | 1.397 g/cm3 |
|---|---|
| Boiling Point | 380.8ºC at 760 mmHg |
| Melting Point | 219-220 °C (dec.)(lit.) |
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.15700 |
| Flash Point | 198.3ºC |
| Exact Mass | 180.04200 |
| PSA | 74.60000 |
| LogP | 0.58840 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.705 |
| InChIKey | KKADPXVIOXHVKN-UHFFFAOYSA-N |
| SMILES | O=C(O)C(=O)Cc1ccc(O)cc1 |
| Storage condition | 2-8°C |
| Water Solubility | slightly soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 gm/kg/10D-C
- TOXIC EFFECTS :
- Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
- REFERENCE :
- JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 95,535,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 gm/kg/10D-C
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
- REFERENCE :
- JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 95,535,1968 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
- REFERENCE :
- VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(6),47,1976
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UZ1000000 |
| HS Code | 2918990090 |
Customs
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| MFCD00002591 |
| EINECS 205-852-9 |
| 3-(4-hydroxyphenyl)-2-oxopropanoic acid |
| 4-Hydroxyphenylpyruvic acid |
