CAS 86347-15-1|Medetomidine HCl

Introduction：Basic information about CAS 86347-15-1|Medetomidine HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Medetomidine HCl BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Medetomidine HCl
CAS Number	86347-15-1	Molecular Weight	236.740
Density	/	Boiling Point	381.9ºC at 760 mmHg
Molecular Formula	C₁₃H₁₇ClN₂	Melting Point	164-166°C
MSDS	/	Flash Point	191.3ºC

Names

Name	medetomidine hydrochloride
Synonym	More Synonyms

Medetomidine HCl BiologicalActivity

Description	Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease
References	[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39. [2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71. [3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

Description

Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorMedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Medetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Medetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease

References

[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

[2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

[3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

Chemical & Physical Properties

Boiling Point	381.9ºC at 760 mmHg
Melting Point	164-166°C
Molecular Formula	C₁₃H₁₇ClN₂
Molecular Weight	236.740
Flash Point	191.3ºC
Exact Mass	236.108032
PSA	28.68000
LogP	3.98030
InChIKey	VPNGEIHDPSLNMU-UHFFFAOYSA-N
SMILES	Cc1cccc(C(C)c2cnc[nH]2)c1C.Cl
Storage condition	Refrigerator

Safety Information

HS Code	2942000000

Customs

HS Code	2942000000

Synonyms

4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride

4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)

1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)

(±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride

1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)

medetomidine HCl

UNII:BH210P244U

4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride

Medetomidine (hydrochloride)

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