Introduction：Basic information about CAS 156-86-5|Homoarginine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Homoarginine |
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| CAS Number | 156-86-5 | Molecular Weight | 188.227 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 376.3±52.0 °C at 760 mmHg |
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| Molecular Formula | C7H16N4O2 | Melting Point | / |
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| MSDS | / | Flash Point | 181.4±30.7 °C |
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Names
| Name | L-homoarginine |
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| Synonym | More Synonyms |
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Homoarginine BiologicalActivity
| Description | H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase. |
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| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Others |
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| Target | Human Endogenous Metabolite Alkaline phosphatase |
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| In Vitro | It is found that H-HoArg-OH (L-homoarginine), a homologue of arginine, is a strong inhibitor of human bone and liver alkaline phosphatase while it has virtually no effect on intestinal and placental alkaline phosphatases unlike H-HoArg-OH which inhibits intestinal and placental alkaline phosphatases but not the liver and bone enzymes. These four tissues mentioned are the major contributors to the serum alkaline phosphatase[1]. It is also indicated that low levels of the endogenous amino acid H-HoArg-OH are linked to cardiovascular disease[2]. |
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| References | [1]. Fishman W, et al. L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41. [2]. Atzler D, et al. L-homoarginine and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):83-8. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 376.3±52.0 °C at 760 mmHg |
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| Molecular Formula | C7H16N4O2 |
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| Molecular Weight | 188.227 |
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| Flash Point | 181.4±30.7 °C |
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| Exact Mass | 188.127319 |
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| PSA | 125.22000 |
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| LogP | -1.86 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.587 |
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| InChIKey | QUOGESRFPZDMMT-YFKPBYRVSA-N |
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| SMILES | NC(N)=NCCCCC(N)C(=O)O |
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| Storage condition | Store at RT. |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OL5550000
- CHEMICAL NAME :
- Lysine, N(sup 6)-amidino-, L-
- CAS REGISTRY NUMBER :
- 156-86-5
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C7-H16-N4-O2
- MOLECULAR WEIGHT :
- 188.27
- WISWESSER LINE NOTATION :
- QVYZ4MYZUM
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 44500 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,1072,1982
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Safety Information
| Hazard Codes | Xn,N,Xi |
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| Risk Phrases | R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . |
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| Safety Phrases | S36/37/39-S60-S61 |
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| RIDADR | UN 3077 9/PG 3 |
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| WGK Germany | 3 |
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| RTECS | AG3500000 |
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| HS Code | 29152900 |
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Customs
| HS Code | 2925290090 |
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| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| (S)-2-Amino-6-guanidinohexanoic acid |
| N6-(Aminoiminomethyl)-L-lysine |
| H-HOARG-OH |
| Homoarginine |
| MFCD00237108 |
| L-Homoarginine |
| L-Lysine, N6- (aminoiminomethyl)- |
| N-Carbamimidoyl-L-lysine |
| N6-amidino-L-Lysine |
| N6-Carbamimidoyl-L-lysin |
| H-HAR-OH |
| L-Lysine, N-(aminoiminomethyl)- |
| H-HOMOARGININE |
| H-HOMOARG-OH |
| Homo-L-arginine |
| N6-carbamimidoyl-L-lysine |
| l-lysin |
