CAS 53213-83-5|DiOC7(3)

Introduction：Basic information about CAS 53213-83-5|DiOC7(3), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. DiOC7(3) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles4
6. Synonyms

Common Name	DiOC7(3)
CAS Number	53213-83-5	Molecular Weight	600.57400
Density	/	Boiling Point	/
Molecular Formula	C₃₁H₄₁IN₂O₂	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07, GHS08	Signal Word	Danger

Names

Name	3,3'-diheptyloxacarbocyanine iodide
Synonym	More Synonyms

DiOC7(3) BiologicalActivity

Description	DiOC7(3) (3,3'-Diheptyloxacarbocyanine iodide) is a green membrane potential probe (Ex=450-490 nm, Em=510-520 nm). DiOC7(3) can be used to quantify the vascular densities[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others
In Vivo	Identification for tumour vasculature (frozen section): Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[1]. 1. The dye is administered to murine via lateral tail vein injection at a dose of 1 mg/kg/ in 50 μL volume. 2. Animals are killed 5 min after dye administration, and tumors are immediately excised and frozen at - 20°C. 3. Frozen sections 10 μm in thickness are rewarmed to room temperature, allowed to air dry. 4. Image using a microscope with 100W mercury lamp illumination and an epifluorescence condenser (excited at 430-490 nm, emitted at 510-520 nm.
References	[1]. M J Trotter, et al. Use of a carbocyanine dye as a marker of functional vasculature in murine tumours. Br J Cancer. 1989 May;59(5):706-9.

Chemical & Physical Properties

Molecular Formula	C₃₁H₄₁IN₂O₂
Molecular Weight	600.57400
Exact Mass	600.22100
PSA	35.09000
LogP	4.98780
InChIKey	ANJZLSIIEGUCQL-UHFFFAOYSA-M
SMILES	CCCCCCCN1C(=CC=Cc2oc3ccccc3[n+]2CCCCCCC)Oc2ccccc21.[I-]

Safety Information

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H315-H319-H335-H360
Precautionary Statements	P201-P261-P305 + P351 + P338-P308 + P313
Personal Protective Equipment	Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R61;R36/37/38
Safety Phrases	S53
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles4

Tissue penetration and activity of camptothecins in solid tumor xenografts.

Mol. Cancer Ther. 13(11) , 2727-37, (2014)

The ability of a panel of camptothecin derivatives to access the tumor compartment was evaluated to determine the mechanisms by which the architecture of solid tumors may act to limit their activity. ...

Use of a carbocyanine dye as a marker of functional vasculature in murine tumours.

Br. J. Cancer 59 , 706, (1989)

An intravenously administered fluorescent carbocyanine dye, DiOC7(3), has been evaluated for use in conjunction with Hoechst 33342 as a marker of murine tumour vasculature. DiOC7(3) stains cells immed...

Pontentiometric cyanine dyes are sensitive probes for mitochondria in intact plant cells : kinetin enhances mitochondrial fluorescence.

Plant Physiol. 84 , 1385, (1987)

Selected fluorescent dyes were tested for uptake by mitochrondria in intact cells of barley, maize, and onion. The cationic cyanine dye 3,3'-diheptyloxacarbocyanine iodide [DiOC(7)(3)] accumulated in ...

Synonyms

BENZOXAZOLIUM,3-HEPTYL-2-[3-(3-HEPTYL-2(3H)-BENZOXAZOLYLIDENE)-1-PROPENYL]-,IODIDE

MFCD00274413

D 378

3-HEPTYL-2-((E)-3-[3-HEPTYL-1,3-BENZOXAZOL-2(3H)-YLIDENE]-1-PROPENYL)-1,3-BENZOXAZOL-3-IUM IODIDE

3,3''-DIHEPTYLOXACARBOCYANINE IODIDE [DIOC7(3)]

3,3-diheptyloxacarboxycyanine iodide

DiOC7(3) [3,3'-Diheptyloxacarbocyanine iodide]

DIOC7(3)

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