CAS 75144-12-6|Antitrypanosomal agent 1

Introduction：Basic information about CAS 75144-12-6|Antitrypanosomal agent 1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Antitrypanosomal agent 1 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Antitrypanosomal agent 1
CAS Number	75144-12-6	Molecular Weight	282.59400
Density	1.22g/cm3	Boiling Point	341.9ºC at 760 mmHg
Molecular Formula	C₁₁H₁₄Cl₃NO	Melting Point	/
MSDS	/	Flash Point	160.6ºC

Names

Name	1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one,hydrochloride
Synonym	More Synonyms

Antitrypanosomal agent 1 BiologicalActivity

Description	Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].
Related Catalog	Research Areas >>Infection
Target	IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)[1] EC50: 1 μM (T. brucei)[1]
In Vitro	Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20[1].
References	[1]. Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3.

Chemical & Physical Properties

Density	1.22g/cm3
Boiling Point	341.9ºC at 760 mmHg
Molecular Formula	C₁₁H₁₄Cl₃NO
Molecular Weight	282.59400
Flash Point	160.6ºC
Exact Mass	281.01400
PSA	20.31000
LogP	3.92980
Index of Refraction	1.544
InChIKey	PRRKQCKNKRZOPV-UHFFFAOYSA-N
SMILES	CN(C)CCC(=O)c1ccc(Cl)c(Cl)c1.Cl
Storage condition	2-8℃

Synonyms

1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl

AmbscPOD_38/0850

1-(3,4-dichlorophenyl)-3-dimethylamino-1-propanone hydrochloride

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