Introduction：Basic information about CAS 53005-05-3|4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID |
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| CAS Number | 53005-05-3 | Molecular Weight | 454.52000 |
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| Density | 1.54g/cm3 | Boiling Point | / |
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| Molecular Formula | C16H10N2O6S4 | Melting Point | >400ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>RAD51 |
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| In Vitro | DIDS (0-10 μM) 抑制 RAD51 介导的链交换[1]。 DIDS (0-20 μM) 通过 RAD51 抑制 DNA 结合[1]。 DIDS (10 μM; 0-60 分钟) 在 DNA 不存在的情况下刺激 RAD51 的 ATP 水解活性[1]。 |
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| References | [1]. Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76. [2]. Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4'-diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77. |
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Chemical & Physical Properties
| Density | 1.54g/cm3 |
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| Melting Point | >400ºC |
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| Molecular Formula | C16H10N2O6S4 |
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| Molecular Weight | 454.52000 |
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| Exact Mass | 453.94200 |
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| PSA | 214.40000 |
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| LogP | 5.98060 |
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| Index of Refraction | 1.693 |
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| InChIKey | YSCNMFDFYJUPEF-OWOJBTEDSA-N |
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| SMILES | O=S(=O)(O)c1cc(N=C=S)ccc1C=Cc1ccc(N=C=S)cc1S(=O)(=O)O |
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Safety Information
Customs
| HS Code | 2930909090 |
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| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| dids |
| 4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid |
| 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid |
| trans-4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid |
| 4,4'-diisothiocyanato-2,2'-stilbenedisulfoneic acid |
| 4,4'-diisothiocyanostilbene-2-2'-disulphonic acid |
| 5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid |
| 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid |
