CAS 126643-37-6|KT5823
| Common Name | KT5823 | ||
|---|---|---|---|
| CAS Number | 126643-37-6 | Molecular Weight | 495.52600 |
| Density | 1.52g/cm3 | Boiling Point | 629.2ºC at 760mmHg |
| Molecular Formula | C29H25N3O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 334.3ºC |
Names
| Name | kt 5823 |
|---|---|
| Synonym | More Synonyms |
KT5823 BiologicalActivity
| Description | KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively[1]. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells[2]. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisSignaling Pathways >>Epigenetics >>PKCSignaling Pathways >>Protein Tyrosine Kinase/RTK >>PKAResearch Areas >>OthersSignaling Pathways >>Stem Cell/Wnt >>PKASignaling Pathways >>TGF-beta/Smad >>PKC |
| Target | PKA:10 μM (Ki) PKC:4 μM (Ki) |
| References | [1]. 1.Gadbois DM, et al. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30. [2]. Wyatt TA, et al. KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):3-14. [3]. Chan SL, et al. Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod. 2003 Dec;9(12):775-83. |
Chemical & Physical Properties
| Density | 1.52g/cm3 |
|---|---|
| Boiling Point | 629.2ºC at 760mmHg |
| Molecular Formula | C29H25N3O5 |
| Molecular Weight | 495.52600 |
| Flash Point | 334.3ºC |
| Exact Mass | 495.17900 |
| PSA | 74.93000 |
| LogP | 4.58930 |
| Vapour Pressure | 9.67E-16mmHg at 25°C |
| Index of Refraction | 1.763 |
| InChIKey | QTYMDECKVKSGSM-YMUMJAELSA-N |
| SMILES | COC(=O)C1(OC)CC2OC1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N(C)C4 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
Articles32
More Articles| Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization. Mol. Pain 11 , 71, (2015) ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is... | |
| Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells. Am. J. Physiol. Cell Physiol. 303(12) , C1260-8, (2012) In this study, the interaction of natriuretic peptides (NP) and bradykinin (BK) signaling pathways was identified by measuring membrane potential (V(m)) and intracellular Ca(2+) using the patch-clamp ... | |
| Cytoprotective effect of 1-nitro-2-phenylethane in mice pancreatic acinar cells subjected to taurocholate: putative role of guanylyl cyclase-derived 8-nitro-cyclic-GMP. Biochem. Pharmacol. 91(2) , 191-201, (2014) The nitroderivative 1-nitro-2-phenylethane (NPE) was recently described as a compound possessing heme-dependent soluble guanylyl cyclase (sGC) stimulating properties in vascular smooth muscle cells. I... |
Synonyms
| MFCD00132119 |
| (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-l][1,6]benzodiazocine-10-carboxylic acid methyl ester |
