Introduction：Basic information about CAS 110368-33-7|Ch 55, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ch 55 |
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| CAS Number | 110368-33-7 | Molecular Weight | 364.47700 |
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| Density | 1.085g/cm3 | Boiling Point | 509.5ºC at 760mmHg |
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| Molecular Formula | C24H28O3 | Melting Point | / |
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| MSDS | / | Flash Point | 276ºC |
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Names
| Name | 4-[(E)-3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid |
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| Synonym | More Synonyms |
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Ch 55 BiologicalActivity
| Description | Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>RAR/RXR |
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| Target | RARα RARβ |
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| In Vitro | Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1]. |
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| References | [1]. Jetten AM, et al. New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein. Cancer Res. 1987 Jul 1;47(13):3523-7. [2]. Takahashi N, et al. Induction of differentiation and covalent binding to proteins by the synthetic retinoids Ch55 and Am80. Arch Biochem Biophys. 1994 Oct;314(1):82-9. |
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Chemical & Physical Properties
| Density | 1.085g/cm3 |
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| Boiling Point | 509.5ºC at 760mmHg |
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| Molecular Formula | C24H28O3 |
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| Molecular Weight | 364.47700 |
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| Flash Point | 276ºC |
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| Exact Mass | 364.20400 |
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| PSA | 54.37000 |
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| LogP | 5.87590 |
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| Vapour Pressure | 3.33E-11mmHg at 25°C |
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| Index of Refraction | 1.574 |
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Safety Information
Customs
| HS Code | 2918300090 |
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| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| 3,5-di-tert-butylchalcone 4'-carboxylic acid |
| CH 55 |
| 3,5-Di-tert-butylchalcone |
