Introduction：Basic information about CAS 116700-36-8|H-9 dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-9 dihydrochloride |
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| CAS Number | 116700-36-8 | Molecular Weight | 324.227 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C11H15Cl2N3O2S | Melting Point | 250-255ºC dec. |
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| MSDS | / | Flash Point | / |
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Names
| Name | h-9 dihydrochloride |
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| Synonym | More Synonyms |
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H-9 dihydrochloride BiologicalActivity
| Description | H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3]. |
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| Related Catalog | Signaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>PKASignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFRSignaling Pathways >>Stem Cell/Wnt >>PKAResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| In Vitro | H-9 Dihydrochloride significantly inhibits A431 cells[1]. H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases[1]. |
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| In Vivo | H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration[2]. |
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| References | [1]. Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10(3):211-6. [2]. Vázquez-López A, et al. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005 May;30(5):613-8. [3]. Wollina U, et al. Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med. 2003 Oct;12(4):673-7. |
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Chemical & Physical Properties
| Melting Point | 250-255ºC dec. |
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| Molecular Formula | C11H15Cl2N3O2S |
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| Molecular Weight | 324.227 |
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| Exact Mass | 323.026215 |
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| PSA | 93.46000 |
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| LogP | 4.24780 |
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| InChIKey | HBLCYSFLYMHCBM-UHFFFAOYSA-N |
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| SMILES | Cl.Cl.NCCNS(=O)(=O)c1cccc2cnccc12 |
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| Storage condition | −20°C |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26-36 |
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| WGK Germany | 3 |
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| HS Code | 2935009090 |
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Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
| N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride |
| 5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, hydrochloride (1:2) |
| N-(2-Aminoethyl)isoquinoline-5-sulfonamide dihydrochloride |
| MFCD00069286 |
