CAS 142720-24-9|FGIN-1-27
| Common Name | FGIN-1-27 | ||
|---|---|---|---|
| CAS Number | 142720-24-9 | Molecular Weight | 436.60500 |
| Density | 1.073g/cm3 | Boiling Point | 608.3ºC at 760mmHg |
| Molecular Formula | C28H37FN2O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 321.7ºC |
Names
| Name | 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide |
|---|---|
| Synonym | More Synonyms |
FGIN-1-27 BiologicalActivity
| Description | FGIN 1-27, an indoleacetamide, is a specific peripheral benzodiazepine receptor (PBR) ligand with a Ki of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| References | [1]. Michelle L James, et al. Development of ligands for the peripheral benzodiazepine receptor. Curr Med Chem. 2006;13(17):1991-2001. |
Chemical & Physical Properties
| Density | 1.073g/cm3 |
|---|---|
| Boiling Point | 608.3ºC at 760mmHg |
| Molecular Formula | C28H37FN2O |
| Molecular Weight | 436.60500 |
| Flash Point | 321.7ºC |
| Exact Mass | 436.28900 |
| PSA | 36.10000 |
| LogP | 7.50570 |
| Vapour Pressure | 9.6E-15mmHg at 25°C |
| Index of Refraction | 1.562 |
| InChIKey | VUWXAQFLTSBUDB-UHFFFAOYSA-N |
| SMILES | CCCCCCN(CCCCCC)C(=O)Cc1c(-c2ccc(F)cc2)[nH]c2ccccc12 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
Articles29
More Articles| Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands. Bioorg. Med. Chem. 12(2) , 423-38, (2004) Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiol... | |
| Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis. Biochem. Pharmacol. 97 , 99-110, (2015) As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the developm... | |
| Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Br. J. Cancer 89(3) , 564-72, (2003) Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce apoptosis and cell cycle arrest in oesophageal cancer cells. However, the underlying mechanisms are still unknown. ... |
Synonyms
| MFCD00467704 |
| Fgin 1 27 |
| Lopac-D-8555 |
| Tocris-0658 |
| N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide |
