CAS 263717-53-9|PPT
| Common Name | PPT | ||
|---|---|---|---|
| CAS Number | 263717-53-9 | Molecular Weight | 386.44 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 630.0±55.0 °C at 760 mmHg |
| Molecular Formula | C24H22N2O3 | Melting Point | 230 ºC (decomp) |
| MSDS | ChineseUSA | Flash Point | 334.8±31.5 °C |
Names
| Name | 1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole |
|---|---|
| Synonym | More Synonyms |
PPT BiologicalActivity
| Description | Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERσ) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Cancer |
| Target | Estrogen receptor alpha[1] |
| In Vitro | The EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM in ERα-U2OS-Luc cells[1]. |
| References | [1]. https://www.ncbi.nlm.nih.gov/pubmed/18644836/ [2]. Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43(26):4934-47. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 630.0±55.0 °C at 760 mmHg |
| Melting Point | 230 ºC (decomp) |
| Molecular Formula | C24H22N2O3 |
| Molecular Weight | 386.44 |
| Flash Point | 334.8±31.5 °C |
| Exact Mass | 386.163055 |
| PSA | 78.51000 |
| LogP | 5.95 |
| Appearance of Characters | solid,off-white |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.642 |
| InChIKey | IOTXSIGGFRQYKW-UHFFFAOYSA-N |
| SMILES | CCCc1c(-c2ccc(O)cc2)nn(-c2ccc(O)cc2)c1-c1ccc(O)cc1 |
| Storage condition | 2-8°C |
| Water Solubility | Practically insoluble (0.016 g/L) (25 ºC) |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles7
More Articles| Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice. Environ. Health Perspect. 123(4) , 344-52, (2015) Concerns regarding potential endocrine-disrupting chemicals (EDCs) have led to a need for methods to evaluate candidate estrogenic chemicals. Our previous evaluations of two such EDCs revealed a respo... | |
| Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas. Anticancer Drugs 26(3) , 293-300, (2015) Tamoxifen, a selective estrogen receptor modulator, is widely used in the chemotherapy of estrogen receptor-positive breast cancer. Recent studies have indicated that tamoxifen might have a potential ... | |
| Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells. PLoS ONE 11 , e0151455, (2016) Obesity is a significant risk factor for certain cancers, including hepatocellular carcinoma (HCC). Leptin, a hormone secreted by white adipose tissue, precipitates HCC development. Epidemiology data ... |
Synonyms
| Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris- |
| 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole |
| 4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol |
| 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one |
| 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol |
| Propyl pyrazole triol |
