CAS 87860-39-7|Fostriecin
Introduction：Basic information about CAS 87860-39-7|Fostriecin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fostriecin | ||
|---|---|---|---|
| CAS Number | 87860-39-7 | Molecular Weight | 452.36800 |
| Density | / | Boiling Point | 737.9ºC at 760 mmHg |
| Molecular Formula | C19H26NaO9P | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 400.1ºC |
Names
| Name | Fostriecin sodium salt,(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Boiling Point | 737.9ºC at 760 mmHg |
|---|---|
| Molecular Formula | C19H26NaO9P |
| Molecular Weight | 452.36800 |
| Flash Point | 400.1ºC |
| Exact Mass | 452.12100 |
| PSA | 166.39000 |
| LogP | 1.49330 |
| InChIKey | XBUIKNRVGYFSHL-IAVQPKKASA-M |
| SMILES | CC(O)(C=CC1CC=CC(=O)O1)C(CC(O)C=CC=CC=CCO)OP(=O)([O-])O.[Na+] |
| Storage condition | −20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,921,1986
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UQ0600000 |
Articles6
More Articles| Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae. J. Neurosci. 31 , 5512-25, (2011) An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,... | |
| Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity. Cancer Res. 58 , 3611-3619, (1998) Fostriecin, a structurally unique phosphate ester, is presently under evaluation in clinical trials to determine its potential use as an antitumor drug in humans. Fostriecin has been reported as havin... | |
| Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 416 , 230, (1997) Fostriecin, an antitumor antibiotic produced by Streptomyces pulveraceus, is a strong inhibitor of type 2A (PP2A; IC50 3.2 nM) and a weak inhibitor of type 1 (PP1; IC50 131 microM) serine/threonine pr... |
Synonyms
| PHOSPHOTRIENIN |
| FOSTRIECIN SODIUM SALT |
| cl1565asodiumsalt |
| FOSTRIECIN |
| FST |
| antibioticcl1565asodiumsalt |
| MFCD01939908 |
| FOSTRIECIN SODIUM |
| CL-920 |
| ci920sodiumsalt |
| antibioticci920sodiumsalt |
