CAS 141022-99-3|PACOCF3
| Common Name | PACOCF3 | ||
|---|---|---|---|
| CAS Number | 141022-99-3 | Molecular Weight | 308.423 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 329.0±37.0 °C at 760 mmHg |
| Molecular Formula | C17H31F3O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 227.1±18.0 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | Palmityl trifluoromethyl ketone |
|---|---|
| Synonym | More Synonyms |
PACOCF3 BiologicalActivity
| Description | PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>PhospholipaseResearch Areas >>Inflammation/Immunology |
| Target | PLA2:3.8 μM (IC50) |
| In Vitro | At a concentration of 20 μM, PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca2+]i), but at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca2+]i by activating extracellular Ca2+ entry which is partly suppressed by 50 μM La3+[2]. The effect of PACOCF3 is abolished by removal of extracellular Ca2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca2+]i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca2+ influx without affecting internal Ca2+ release[2]. |
| References | [1]. E J Ackermann, et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270(1):445-50. [2]. C R Jan, et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74(8):447-51. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 329.0±37.0 °C at 760 mmHg |
| Molecular Formula | C17H31F3O |
| Molecular Weight | 308.423 |
| Flash Point | 227.1±18.0 °C |
| Exact Mass | 308.232697 |
| PSA | 17.07000 |
| LogP | 7.93 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.418 |
| InChIKey | MAHYXYTYTLCTQD-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCC(=O)C(F)(F)F |
| Storage condition | -20°C |
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution |
Articles4
More Articles| Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J. Biol. Chem. 270 , 445, (1995) A novel Ca(2+)-independent phospholipase A2 (PLA2) has recently been purified from the murine macrophage-like cell line P388D1 (Ackermann, E. J., Kempner, E. S., and Dennis, E. A. (1994) J. Biol. Chem... | |
| Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim. Biophys. Acta 1302 , 55-60, (1996) Methyl arachidonyl fluorophosphonate (MAFP) has been recently reported to be a selective, active-site directed, irreversible inhibitor of the Group IV 85 kDa cytosolic phospholipase A2 (cPLA2). We hav... | |
| Metabolic oxidation regulates embryonic stem cell differentiation. Nat. Chem. Biol. 6 , 411-7, (2010) Metabolites offer an important unexplored complementary approach to understanding the pluripotency of stem cells. Using MS-based metabolomics, we show that embryonic stem cells are characterized by ab... |
Synonyms
| 2-Heptadecanone, 1,1,1-trifluoro- |
| MFCD00797669 |
| 1,1,1-Trifluoro-2-heptadecanone |
| 1,1,1-trifluoroheptadecan-2-one |
| PACOCF3 Pentadecyl trifluoromethyl ketone |
