CAS 126738-34-9|Sarafotoxin A

Introduction：Basic information about CAS 126738-34-9|Sarafotoxin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameSarafotoxin A
CAS Number126738-34-9Molecular Weight2514.85000
Density/Boiling Point/
Molecular FormulaC105H156N28O34S5Melting Point/
MSDSChineseFlash Point/

Names

NameSarafotoxin S6a
SynonymMore Synonyms

Sarafotoxin A BiologicalActivity

DescriptionSarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM[1].
Related CatalogResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Endothelin ReceptorResearch Areas >>Neurological Disease
Target

ETB

ETA

In VitroSarafotoxin S6a is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC50) is 150 nM in guinea-pig aorta[1].
References

[1]. P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol

Chemical & Physical Properties

Molecular FormulaC105H156N28O34S5
Molecular Weight2514.85000
Exact Mass2512.99000
PSA1144.17000
LogP1.82910
InChIKeyBOQKWORWRAYXSI-UHFFFAOYSA-N
SMILESCCC(C)C(NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C1CSSCC(N)C(=O)NC(CO)C(=O)NC2CSSCC(NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC2=O)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(Cc2ccccc2)C(=O)N1)C(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

Synonyms

SRTX-A,S6A
M.W. 2514.85 C105H156N28O34S5
H-CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH
CHPG Sodium salt
CYS-SER-CYS-LYS-ASP-MET-THR-ASP-LYS-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP
SARAFOTOXIN A
SARAFOTOXIN S6A1
CAS 52906-92-0|Motilin (26-47), human, porcine
CAS 169209-64-7|MSPG
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