CAS 757239-60-4|Methyl 1-Cbz-azetidine-3-carboxylate

Introduction：Basic information about CAS 757239-60-4|Methyl 1-Cbz-azetidine-3-carboxylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMethyl 1-Cbz-azetidine-3-carboxylate
CAS Number757239-60-4Molecular Weight249.262
Density1.3±0.1 g/cm3Boiling Point414.9±45.0 °C at 760 mmHg
Molecular FormulaC13H15NO4Melting Point/
MSDS/Flash Point204.7±28.7 °C

Names

Name1-O-benzyl 3-O-methyl azetidine-1,3-dicarboxylate
SynonymMore Synonyms

Methyl 1-Cbz-azetidine-3-carboxylate BiologicalActivity

DescriptionMethyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
Related CatalogResearch Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

Non-cleavable

In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point414.9±45.0 °C at 760 mmHg
Molecular FormulaC13H15NO4
Molecular Weight249.262
Flash Point204.7±28.7 °C
Exact Mass249.100113
PSA55.84000
LogP1.42
Vapour Pressure0.0±1.0 mmHg at 25°C
Index of Refraction1.580

Safety Information

HS Code2933990090

Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER
1-[(Benzyloxy)carbonyl]-3-methyl-3-azetidinecarboxylic acid
1-Cbz-3-azetidinecarboxylic acid methyl ester
1-Benzyl 3-methyl 1,3-azetidinedicarboxylate
Methyl1-Cbz-azetidine-3-carboxylate
1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE
HT799
Azetidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester
1,3-Azetidinedicarboxylic acid, 3-methyl-, 1-(phenylmethyl) ester
methyl 1-benzyloxycarbonyl-3-azetidinecarboxylate
CAS 75711-01-2|6-Chloro-5-methoxypyridin-3-amine
CAS 758684-29-6|Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylate
Recommended......
CAS 75690-75-4|LHRH (7-10) &mi CAS 7564-64-9|3-Methylpentane- CAS 756-81-0|Silane,diethyldim CAS 7522-27-2|3-CHLORO-N N-BIS CAS 75942-37-9|3 6-DIBUTOXY-1 CAS 75942-39-1|3 6-DIOCTYLOXY- CAS 755039-54-4|(R)-2-chloro-8 CAS 758660-80-9|Butanoic acid, CAS 752923-70-9|1H-Indene-2-ca CAS 752970-45-9|(1-Isopropyl-3 CAS 752981-45-6|7-chloropyrrol CAS 752982-24-4|1-(4-ethynyl-2 CAS 7530-31-6|N-(4-aminophenyl CAS 75315-63-8|benzyl 2,5-diox CAS 75343-44-1|CYCLOPROPYL 4-E CAS 753470-95-0|5,5'-Dibro CAS 75-11-6|Diiodomethane CAS 75091-93-9|trans-4-(Triflu CAS 75980-60-8|Diphenyl(2,4,6- CAS 757172-82-0|thiazolo[5,4-c
Disclaimer

This site is a non-commercial website, not accept any sponsorship and advertising. The content is collated from the Internet, does not represent the position of this site, for personal reference only, please distinguish by yourself! The belongs to the original author.

Copyright © 2025 All Rights Reserved.

TOP