Introduction：Basic information about CAS 1250-95-9|Cholesterol-5α,6α-epoxide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cholesterol-5α,6α-epoxide |
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| CAS Number | 1250-95-9 | Molecular Weight | 402.65300 |
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| Density | 1.04g/cm3 | Boiling Point | 497.7ºC at 760mmHg |
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| Molecular Formula | C27H46O2 | Melting Point | / |
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| MSDS | USA | Flash Point | 200.9ºC |
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Names
| Name | 5,6α-epoxy-5α-cholestan-3β-ol |
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| Synonym | More Synonyms |
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Cholesterol-5α,6α-epoxide BiologicalActivity
| Description | Cholesterol-5α,6α-epoxide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
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| Related Catalog | Research Areas >>Others |
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Chemical & Physical Properties
| Density | 1.04g/cm3 |
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| Boiling Point | 497.7ºC at 760mmHg |
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| Molecular Formula | C27H46O2 |
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| Molecular Weight | 402.65300 |
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| Flash Point | 200.9ºC |
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| Exact Mass | 402.35000 |
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| PSA | 32.76000 |
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| LogP | 6.59990 |
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| Vapour Pressure | 5.43E-12mmHg at 25°C |
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| Index of Refraction | 1.533 |
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| InChIKey | PRYIJAGAEJZDBO-ZEQHCUNVSA-N |
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| SMILES | CC(C)CCCC(C)C1CCC2C3CC4OC45CC(O)CCC5(C)C3CCC12C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- FZ6360000
- CHEMICAL NAME :
- 5-alpha-Cholestan-3-beta-ol, 5,6-alpha-epoxy-
- CAS REGISTRY NUMBER :
- 1250-95-9
- BEILSTEIN REFERENCE NO. :
- 0089511
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C27-H46-O2
- MOLECULAR WEIGHT :
- 402.73
- WISWESSER LINE NOTATION :
- T3 F5 E666 1A R AXO CH&TTTTJ IY1&3Y1&1 J1 QQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 750 mg/kg/9W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 25 umol/L
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1103,1986
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| RTECS | FZ6360000 |
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Articles30
More Articles
| Oxysterols: modulators of cholesterol metabolism and other processes. Physiol. Rev. 80 , 361-554, (2000) Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of biological activities, including effects on sphingolipid metabolism, platelet aggregation, apoptosis, and pro... | |
| Oxysterols as non-genomic regulators of cholesterol homeostasis. Trends Endocrinol. Metab. 23 , 99-106, (2012) Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease... | |
| Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles. J. Lipid Res. 53(4) , 718-25, (2012) We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the... | |
Synonyms
| Cholesterol epoxide |
| 5,6alpha-epoxy-5alpha-cholestan-3beta-ol |
| Cholesterol-5α,6α-epoxide |
| MFCD00046980 |
| Epoxycholesterol |
| cholestanol |
| EINECS 215-007-6 |
| Cholesterol-5alpha,6alpha-epoxide |
