CAS 70431-34-4|Colominic acid sodium salt
| Common Name | Colominic acid sodium salt | ||
|---|---|---|---|
| CAS Number | 70431-34-4 | Molecular Weight | 955.70900 |
| Density | / | Boiling Point | / |
| Molecular Formula | C33H48N3Na3O25 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | trisodium,N-[(2S,3R,4S)-2-[(1R)-1,2-dihydroxyethyl]-4-hydroxy-6-(2-hydroxyethoxy)oxan-3-yl]acetamide |
|---|---|
| Synonym | More Synonyms |
Colominic acid sodium salt BiologicalActivity
| Description | Colominic acid sodium salt (Polysialic acid sodium salt) could be naturally isolated from the cell wall of Escherichia coli and animals, gives a red color which has an absorption maximum at 530 nm. Colominic acid sodium salt (Polysialic acid sodium salt) possesses anti-bacterial activity[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/Immunology |
| In Vitro | Colominic acid (Polysialic acid) is an form of N-glycosylation with great specificity for its limited central nervous system targets, including the cell adhesion molecules neural cell adhesion molecule (NCAM) and synaptic cell adhesion molecule 1 (SynCAM1), and the receptor, neuropilin-2[2]. |
| References | [1]. Guy T. Barry, et al. COLOMINIC ACID, A POLYMER OF N-ACETYLNEURAMINIC ACID. J Exp Med. 1958 Apr 1;107(4):507-21. [2]. Osama I Alwassil, et al. Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection. PLoS One. 2019 Oct 16;14(10):e0223413. |
Chemical & Physical Properties
| Molecular Formula | C33H48N3Na3O25 |
|---|---|
| Molecular Weight | 955.70900 |
| Exact Mass | 955.22700 |
| PSA | 454.37000 |
| InChIKey | IPYNPWIUCZLARC-XAIQJKFESA-N |
| SMILES | CC(=O)NC1C(O)CC(O[CH]CO)OC1C(O)CO.[Na+].[Na+].[Na+] |
| Storage condition | -20°C |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles3
More Articles| An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues. J. Immunol. 138 , 4402-4407, (1987) The structurally similar polysialic acid capsules of group B meningococci and Escherichia coli K1 are poor immunogens, and attempts are currently being made to improve their immunogenicity by chemical... | |
| Polysialic acid units are spatially and temporally expressed in developing postnatal rat kidney. Proc. Natl. Acad. Sci. U. S. A. 84 , 1969-1973, (1987) We report the presence of alpha(2----8)-linked polysialic acid as detected with a monoclonal antibody outside the nervous tissue in the postnatal developing rat kidney. By immunoblot analysis, the rea... | |
| Reexpression of poly(sialic acid) units of the neural cell adhesion molecule in Wilms tumor. Proc. Natl. Acad. Sci. U. S. A. 85 , 2999-3003, (1988) A unique structural feature of the neural cell adhesion molecule N-CAM is the presence of homopolymers of alpha (2----8)-linked sialic acid units. We have used two specific probes for the detection of... |
Synonyms
| Colominic acid sodium salt from Escherichia coli |
| MFCD00133197 |
