Introduction：Basic information about CAS 152-53-4|Cycloguanil Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cycloguanil Hydrochloride |
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| CAS Number | 152-53-4 | Molecular Weight | 288.17600 |
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| Density | / | Boiling Point | 400.7ºC at 760mmHg |
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| Molecular Formula | C11H15Cl2N5 | Melting Point | 210-215ºC |
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| MSDS | / | Flash Point | 196.1ºC |
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Names
| Name | 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine,hydrochloride |
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| Synonym | More Synonyms |
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Cycloguanil Hydrochloride BiologicalActivity
| Description | Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
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| References | [1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200. |
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Chemical & Physical Properties
| Boiling Point | 400.7ºC at 760mmHg |
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| Melting Point | 210-215ºC |
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| Molecular Formula | C11H15Cl2N5 |
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| Molecular Weight | 288.17600 |
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| Flash Point | 196.1ºC |
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| Exact Mass | 287.07000 |
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| PSA | 80.00000 |
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| LogP | 2.66430 |
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| Vapour Pressure | 1.25E-06mmHg at 25°C |
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| InChIKey | MOUAPRKJJUXEIE-UHFFFAOYSA-N |
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| SMILES | CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1.Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GU2625000
- CHEMICAL NAME :
- Cycloguanil hydrochloride
- CAS REGISTRY NUMBER :
- 152-53-4
- LAST UPDATED :
- 199106
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C11-H14-Cl-N5.Cl-H
- MOLECULAR WEIGHT :
- 288.21
- WISWESSER LINE NOTATION :
- T6N CN EN BHJ AR DG& B1 B1 DZ FZ &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 54 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,487,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton, Inc., POB 6280, Duluth, MN 55806) V.1- 1907- Volume(issue)/page/year: 74,393,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,487,1971
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Safety Information
Synonyms
| 1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine,hydrochloride |
| 4,6-diamino-1-(4'-chlorophenyl)-1,2-dihydro-2,2-dimethyl-1,3,5-triazine |
| CYCLOGUANIL HYDROCHLORIDE |
| BN 2410 |
| Chloroguanide triazine hydrochloride |
| 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride |
| 1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL |
| 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine monohydrochloride |
| 1-(4'-chlorophenyl)-2,2-dimethyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride |
| 1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin,Hydrochlorid |
