Introduction：Basic information about CAS 21453-69-0|(+)-syringaresinol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (+)-syringaresinol |
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| CAS Number | 21453-69-0 | Molecular Weight | 418.437 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 594.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H26O8 | Melting Point | / |
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| MSDS | / | Flash Point | 313.5±30.1 °C |
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Names
| Name | (+)-syringaresinol |
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| Synonym | More Synonyms |
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(+)-syringaresinol BiologicalActivity
| Description | (+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| Target | IC50: 329.4 μM (NFAT transcription factor)[1] |
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| In Vitro | (+)-Syringaresinol inhibits the growth of P-388 cells, with an ED50 0.41 μg/mL[1]. |
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| References | [1]. Cai XF, et, al. Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum. Arch Pharm Res. 2004 Jul;27(7):738-41. [2]. Badawi MM, et, al. Plant anticancer agents XXVII: Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymelaeaceae). J Pharm Sci. 1983 Nov;72(11):1285-7. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 594.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H26O8 |
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| Molecular Weight | 418.437 |
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| Flash Point | 313.5±30.1 °C |
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| Exact Mass | 418.162781 |
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| PSA | 95.84000 |
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| LogP | 0.71 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.578 |
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| InChIKey | KOWMJRJXZMEZLD-HCIHMXRSSA-N |
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| SMILES | COc1cc(C2OCC3C(c4cc(OC)c(O)c(OC)c4)OCC23)cc(OC)c1O |
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Synonyms
| syringaresinol |
| (+)-(7S,7'S,8R,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7,9':7',9-diepoxylignane |
| 4,4'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2,6-dimethoxyphenol) |
| Phenol, 4,4'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2,6-dimethoxy- |
| (-) Syringaresinol |
| (+)-lirioresinol B |
| (+/-)-syringaresinol |
| 4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxyphenyl] |
