CAS 309726-06-5|Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)

Introduction：Basic information about CAS 309726-06-5|Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs

Common Name	Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)
CAS Number	309726-06-5	Molecular Weight	251.32600
Density	/	Boiling Point	/
Molecular Formula	C₁₆H₁₇N₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	2,4,7,9-tetramethylbenzo[b][1,8]naphthyridin-5-amine

BiologicalActivity

Description	BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis
References	[1]. RPA194, rRNA synthesis, 45S Rrna, anticancerKarita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

Chemical & Physical Properties

Molecular Formula	C₁₆H₁₇N₃
Molecular Weight	251.32600
Exact Mass	251.14200
PSA	51.80000
LogP	4.18000
InChIKey	ZNPSDSMZKLWRLO-UHFFFAOYSA-N
SMILES	Cc1cc(C)c2nc3nc(C)cc(C)c3c(N)c2c1

Safety Information

HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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