CAS 11006-33-0|Phleomycin
Introduction：Basic information about CAS 11006-33-0|Phleomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Phleomycin | ||
|---|---|---|---|
| CAS Number | 11006-33-0 | Molecular Weight | 1324.38000 |
| Density | 1.83 g/cm3 | Boiling Point | 1718.8ºC at 760 mmHg |
| Molecular Formula | C52H75N16O21S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 993.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | phleomycin from strepomyces verticillus |
|---|---|
| Synonym | More Synonyms |
Phleomycin BiologicalActivity
| Description | Phleomycin is a wide-spectrum glycopeptide antibiotic found in Streptomyces verticillus. Phleomycin, an effective DNA-cleaving agent, binds and intercalates DNA to damage the integrity of the double helix, which is similar to Bleomycin (HY-17565A)[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Anti-infection >>Bacterial |
| Target | IC50: Antibiotic[1] |
| References | [1]. Kamila Stokowa-Sołtys, et al. Phleomycin complex - Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82. |
Chemical & Physical Properties
| Density | 1.83 g/cm3 |
|---|---|
| Boiling Point | 1718.8ºC at 760 mmHg |
| Molecular Formula | C52H75N16O21S2 |
| Molecular Weight | 1324.38000 |
| Flash Point | 993.3ºC |
| Exact Mass | 1323.47000 |
| PSA | 664.89000 |
| Appearance of Characters | light blue |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.777 |
| InChIKey | QRBLKGHRWFGINE-UHFFFAOYSA-N |
| SMILES | CC(=O)C(NC(=O)C(C)C(O)C(C)NC(=O)C(NC(=O)c1nc(C(CC(N)=O)NCC(N)C(N)=O)nc(N)c1C)C(OC1OC(CO)C(O)C(O)C1(C)OC1OC(CO)C(O)C(O)(C(N)=O)C1O)c1cnc[nH]1)C(=O)NCCC1=NC(c2nc(C(N)=O)cs2)CS1 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 10 mg/mL, clear, blue |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 649 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 371 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg/10D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Ovary
- DOSE/DURATION :
- 1 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 6,289,1968
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Ovary
- DOSE/DURATION :
- 1 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 6,289,1968
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful;Xi: Irritant; |
| Risk Phrases | R22 |
| Safety Phrases | 26-36 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | SY0525000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
Articles6
More Articles| CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei. Mol. Biochem. Parasitol. 157(1) , 73-82, (2008) The limited repertoire of drug-resistance markers imposes a serious obstacle to genetic manipulation of Trypanosoma brucei. Here we describe experiments with a fusion protein that allows positive sele... | |
| Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding. Biochemistry 20 , 665-671, (1981) The kinetics and mechanism of binding of Cu-(II).bleomycin, Fe(III).bleomycin, and Cu(II).phleomycin to DNA were studied by using fluorometry, equilibrium dialysis, electric dichroism, and temperature... | |
| Sulphydryl-mediated DNA breakage by phlemomycin in Escherichia coli. Mutat. Res. 42 , 181-190, (1977) Sulphydryl-mediated DNA breakage, which is induced by the antibiotic phleomycin in vitro, has been found to contribute significantly to the DNA damage produced by phleomycin in Escherichia coli. The e... |
Synonyms
| PHLEOMYCIN |
| MFCD00131846 |
| phleomycincomplex |
| PHLEOMYCIN (STREPTOMYCES VERTICILLUS) |
| phleomycin from streptomyces*verticillus |
| ZEOCIN(TM) |
