Introduction：Basic information about CAS 2030-63-9|Clofazimine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Clofazimine |
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| CAS Number | 2030-63-9 | Molecular Weight | 473.396 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 566.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C27H22Cl2N4 | Melting Point | 210-212° |
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| MSDS | ChineseUSA | Flash Point | 296.7±30.1 °C |
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Names
| Name | clofazimine |
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| Synonym | More Synonyms |
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Clofazimine BiologicalActivity
| Description | Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialDye ReagentsResearch Areas >>Inflammation/Immunology |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 566.9±50.0 °C at 760 mmHg |
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| Melting Point | 210-212° |
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| Molecular Formula | C27H22Cl2N4 |
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| Molecular Weight | 473.396 |
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| Flash Point | 296.7±30.1 °C |
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| Exact Mass | 472.122162 |
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| PSA | 42.21000 |
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| LogP | 7.26 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.667 |
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| InChIKey | WDQPAMHFFCXSNU-UHFFFAOYSA-N |
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| SMILES | CC(C)N=c1cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1 |
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| Water Solubility | Practically insoluble in water, soluble in methylene chloride, very slightly soluble in ethanol (96 per cent). It shows polymorphism (5.9). |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SG1578000
- CHEMICAL NAME :
- Phenazine, 2,10-dihydro-3-(p-chloroanilino)-10-(p-chlorophenyl)- 2-(isopropylimino)-
- CAS REGISTRY NUMBER :
- 2030-63-9
- BEILSTEIN REFERENCE NO. :
- 0060420
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C27-H22-Cl2-N4
- MOLECULAR WEIGHT :
- 473.43
- WISWESSER LINE NOTATION :
- T C666 BN IN EHJ BR DG& ENUY1&1 FMR DG
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 32,911,1994
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Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xn:Harmful; |
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| Risk Phrases | R22 |
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| Safety Phrases | S36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | SG1578000 |
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| HS Code | 35040000 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]- |
| N,5-Bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydro-2-phenazinamine |
| Clofaziminum [INN-Latin] |
| 2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)- |
| Clofazimine |
| Clofaziminum |
| N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine |
| Chlofazimine |
| Clofazimine (N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine |
| Clofazimina [INN-Spanish] |
| Lamprene |
| Lampren |
| 2-(4-chloro-anilino)-5-(4-chloro-phenyl)-3-isopropylamino-phenazinium-betaine |
| 2-(4-Chlor-anilino)-5-(4-chlor-phenyl)-3-isopropylamino-phenazinium-betain |
| B 663 (Pharmaceutical) |
| N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine |
| Clofazimina |
