CAS 67604-48-2|(±)-Naringenin
| Common Name | (±)-Naringenin | ||
|---|---|---|---|
| CAS Number | 67604-48-2 | Molecular Weight | 272.25300 |
| Density | 1.485g/cm3 | Boiling Point | 577.5ºC at 760mmHg |
| Molecular Formula | C15H12O5 | Melting Point | 247-250 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
|---|---|
| Synonym | More Synonyms |
(±)-Naringenin BiologicalActivity
| Description | (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| References | [1]. Saponara S, et al. (+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells. Br J Pharmacol. 2006 Dec;149(8):1013-21. |
Chemical & Physical Properties
| Density | 1.485g/cm3 |
|---|---|
| Boiling Point | 577.5ºC at 760mmHg |
| Melting Point | 247-250 °C(lit.) |
| Molecular Formula | C15H12O5 |
| Molecular Weight | 272.25300 |
| Exact Mass | 272.06800 |
| PSA | 83.83000 |
| LogP | 2.13750 |
| InChIKey | FTVWIRXFELQLPI-UHFFFAOYSA-N |
| SMILES | O=C1CC(c2ccc(O)cc2)Oc2cc(O)cc(O)c21 |
| Storage condition | 0-6°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DJ2981530 |
Articles87
More Articles| The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014) SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that... | |
| Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity. Br. J. Nutr. 113(5) , 770-82, (2015) Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic β-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin ... | |
| Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume. PLoS ONE 10 , e0132791, (2015) Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in... |
Synonyms
| Naringenin |
| (+)-(2R)-naringenin |
| (R)-naringenin |
| 4',5,7-Trihydroxyflavanone |
| 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone |
| (+)-Naringenin |
| MFCD00006844 |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one |
| Naringenine |
| EINECS 266-769-1 |
