CAS 80-50-2|Endovalpin

Introduction：Basic information about CAS 80-50-2|Endovalpin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Endovalpin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles5
7. Synonyms

Common Name	Endovalpin
CAS Number	80-50-2	Molecular Weight	525.63200
Density	/	Boiling Point	/
Molecular Formula	C₂₇H₄₃NO₉	Melting Point	329ºC
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07, GHS09	Signal Word	Warning

Names

Name	anisotropine methylbromide
Synonym	More Synonyms

Endovalpin BiologicalActivity

Description	Anisotropine methobromide is an orally active anticholinergic muscarinic antagonist. Anisotropine methobromide can inhibit gastric acid secretion and is used as an adjunct to peptic ulcers[1].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Metabolic Disease
In Vivo	Anisotropine methobromide (intravenous injection, 0.5 μM and 0.1 mL, once) can block acetylcholine-induced vocalization, intestinal spasm and intestinal contractions in conscious or anesthetized dogs[1]. Animal Model: Dogs weighing 2.5 to 5.0 kg[1] Dosage: 0.5 μM, 0.1 mL Administration: Intravenous injection; once Result: Inhibited the acetylcholine-induced vocalization with maximum inhibition of 85.1% and the acetylcholine-induced intestinal spasm with maximum inhibition of 79%.
References	[1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20.

Chemical & Physical Properties

Melting Point	329ºC
Molecular Formula	C₂₇H₄₃NO₉
Molecular Weight	525.63200
Exact Mass	525.29400
PSA	174.31000
InChIKey	QSFKGMJOKUZAJM-UHFFFAOYSA-M
SMILES	CCCC(CCC)C(=O)OC1CC2CCC(C1)[N+]2(C)C.[Br-]
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM3710000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropanium, 3-alpha-hydroxy-8-methyl-, bromide, 2-propylvalerate

CAS REGISTRY NUMBER :: 80-50-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H32-N-O2.Br

MOLECULAR WEIGHT :: 362.41

WISWESSER LINE NOTATION :: T56 A AKTJ A1 A1 GOVY3&3 &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 705 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2759 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 197 (estimated) No. of Female Employees: 59 (estimated)

Safety Information

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H312-H332-H400
Precautionary Statements	P273-P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;N: Dangerous for the environment;
Risk Phrases	R20/21/22
Safety Phrases	36-61-60
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	YM3710000

Articles5

[Pediatric use of a drug, anticholinergic and muscle relaxant on the gastrointestinal tract].

Pediatr. Med. Chir. 4(1-2) , 79-81, (1982)

[Effectiveness of octatropine methylbromide (OMB) in the treatment of gastritis, duodenal ulcer and spastic colon--a double blind study].

ZFA (Stuttgart.) 58(27) , 1481-4, (1982)

[Preliminary clinical research on a new anti-ulcer drug].

Clin. Ter. 89(4) , 365-71, (1979)

Synonyms

octatropine methylbromide

Methoxy(benzene-2,4,6-d3)

Anisole-2,4,6-d3

1,3,5-trideuterio-2-methoxy-benzene

CHOLINE IODIDE 1-HYDROXY-α-PHENYLCYCLOPENTANEACETATE

2,4,6-Trideutero-anisol

anisotropine methobromide

2,4,6-Trideuterio-anisol

anisotropine methyl bromide

2,4,6-trideuterioanisole

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