Introduction：Basic information about CAS 1152311-62-0|Tezacaftor(VX-661), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tezacaftor(VX-661) |
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| CAS Number | 1152311-62-0 | Molecular Weight | 520.498 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 610.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C26H27F3N2O6 | Melting Point | / |
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| MSDS | / | Flash Point | 323.2±31.5 °C |
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Names
| Name | 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide |
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| Synonym | More Synonyms |
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Tezacaftor(VX-661) BiologicalActivity
| Description | VX-661 is a second F508del CFTR corrector and help CFTR protein reach the cell surface. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>CFTRResearch Areas >>Cancer |
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| In Vitro | In vitro, a combination of VX-661 and ivacaftor results in greater CFTR activity compared with VX-661 alone[2]. |
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| References | [1]. Treatment with VX-661 and Ivacaftor in a Phase 2 Study Resulted in Statistically Significant Improvements in Lung Function in People with Cystic Fibrosis Who Have Two Copies of the F508del Mutation. April 18, 2013 |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 610.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C26H27F3N2O6 |
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| Molecular Weight | 520.498 |
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| Flash Point | 323.2±31.5 °C |
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| Exact Mass | 520.182129 |
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| PSA | 113.18000 |
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| LogP | 2.65 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.628 |
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| InChIKey | MJUVRTYWUMPBTR-MRXNPFEDSA-N |
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| SMILES | CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1CC(O)CO |
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| Storage condition | -20℃ |
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Synonyms
| Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]- |
| tezacaftorum |
| vx661 |
| (r)-1-(2,2-difluorobenzo[d] [1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
| cs-1078 |
| 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-{1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methyl-2-propanyl)-1H-indol-5-yl}cyclopropanecarboxamide |
| Tezacaftor |
