CAS 207556-07-8|MPP+-d3(iodide)
| Common Name | MPP+-d3(iodide) | ||
|---|---|---|---|
| CAS Number | 207556-07-8 | Molecular Weight | 300.15 |
| Density | / | Boiling Point | / |
| Molecular Formula | C12H9D3IN | Melting Point | 168-169ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 4-phenyl-1-(trideuteriomethyl)pyridin-1-ium,iodide |
|---|---|
| Synonym | More Synonyms |
MPP+-d3(iodide) BiologicalActivity
| Description | MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Neurological Disease |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394. [3]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45. [4]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118. |
Chemical & Physical Properties
| Melting Point | 168-169ºC(lit.) |
|---|---|
| Molecular Formula | C12H9D3IN |
| Molecular Weight | 300.15 |
| Exact Mass | 300.02000 |
| PSA | 3.88000 |
| InChIKey | RFDFRDXIIKROAI-NIIDSAIPSA-M |
| SMILES | C[n+]1ccc(-c2ccccc2)cc1.[I-] |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H315-H319-H335 |
| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
| RIDADR | UN 2811 6.1/PG 2 |
Synonyms
| N-Methyl-d3-4-phenylpyridinium iodide |
| MPP+-d3 Iodide |
| MFCD00134220 |
