Introduction：Basic information about CAS 849206-43-5|Olmesartan lactone impurity, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Olmesartan lactone impurity |
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| CAS Number | 849206-43-5 | Molecular Weight | 428.48600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C24H24N6O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 6,6-dimethyl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]furo[3,4-d]imidazol-4-one |
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Olmesartan lactone impurity BiologicalActivity
| Description | Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Angiotensin Receptor |
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| References | [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7. [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9. |
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Chemical & Physical Properties
| Molecular Formula | C24H24N6O2 |
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| Molecular Weight | 428.48600 |
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| Exact Mass | 428.19600 |
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| PSA | 98.58000 |
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| LogP | 4.13650 |
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| InChIKey | JUQNVWFXORBZQJ-UHFFFAOYSA-N |
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| SMILES | CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)OC2(C)C |
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Safety Information
| RIDADR | NONH for all modes of transport |
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