Introduction：Basic information about CAS 20298-86-6|phycocyanobilin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | phycocyanobilin |
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| CAS Number | 20298-86-6 | Molecular Weight | 586.67800 |
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| Density | 1.31±0.1 g/cm3 | Boiling Point | 892.1±65.0 °C |
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| Molecular Formula | C33H38N4O6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (3E)-phycocyanobilin |
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| Synonym | More Synonyms |
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phycocyanobilin BiologicalActivity
| Description | Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| In Vitro | Phycocyanobilin (100 μM; 0-250 min) 抑制亚油酸甲酯的过氧化，并产生较长的诱导期[1]。 Phycocyanobilin (1 mM; 0-300 min) 抑制脂质体的氧化[1]。 |
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| In Vivo | Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) 在 2 型糖尿病小鼠中显示抗氧化作用[3]。 Animal Model: Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes[3] Dosage: 15 mg/kg Administration: In diet for 2 weeks Result: Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1. |
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| References | [1]. Hirata T, et al. Antioxidant activities of phycocyanobilin prepared from Spirulina platensis. Journal of Applied Phycology, 2000, 12: 435-439. [2]. Matamoros BP, et al. Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer's disease. J Biosci. 2021;46:42. [3]. Zheng J, et al. Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R110-20. |
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Chemical & Physical Properties
| Density | 1.31±0.1 g/cm3 |
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| Boiling Point | 892.1±65.0 °C |
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| Molecular Formula | C33H38N4O6 |
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| Molecular Weight | 586.67800 |
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| Exact Mass | 586.27900 |
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| PSA | 164.71000 |
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| LogP | 3.12850 |
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| InChIKey | NNMALANKTSRILL-GSZAROSWSA-N |
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| SMILES | CC=C1C(=Cc2[nH]c(C=c3[nH]c(=CC4=NC(=O)C(CC)=C4C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC(=O)C1C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 3203001990 |
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Customs
Synonyms
| 3-[(2Z,5E)-2-[[3-(2-carboxyethyl)-5-[(Z)-[(3E,4R)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid |
| phycocyanobilin |
| 3,3'-(18-ethyl-3-ethylidene-2,7,13,17-tetramethyl-1,19-dioxo-1,2,3,19,22,24-hexahydro-21H-biline-8,12-diyl)-bis-propionic acid |
| Phycobilin |
| 21H-Biline-8,12-dipropanoic acid,18-ethyl-3-ethylidene-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-,(2R,3E) |
