Introduction：Basic information about CAS 2196-60-3|(+)-Coclaurine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (+)-Coclaurine |
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| CAS Number | 2196-60-3 | Molecular Weight | 285.33800 |
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| Density | 1.232g/cm3 | Boiling Point | 496.9ºC at 760 mmHg |
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| Molecular Formula | C17H19NO3 | Melting Point | 222-224 °C |
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| MSDS | / | Flash Point | 254.3ºC |
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Names
| Name | (R)-coclaurine |
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| Synonym | More Synonyms |
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(+)-Coclaurine BiologicalActivity
| Description | (+)-Coclaurine ((+)-(R)-Coclaurine), benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine has anti-aging activity[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum[2]. |
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| References | [1]. Siva S Panda, et al. Protective effects of Aporosa octandra bark extract against D-galactose induced cognitive impairment and oxidative stress in mice. Heliyon. 2018 Nov 30;4(11):e00951. [2]. H Watanabe, et al. Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum. J Pharmacobiodyn. 1983 Oct;6(10):793-6. |
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Chemical & Physical Properties
| Density | 1.232g/cm3 |
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| Boiling Point | 496.9ºC at 760 mmHg |
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| Melting Point | 222-224 °C |
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| Molecular Formula | C17H19NO3 |
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| Molecular Weight | 285.33800 |
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| Flash Point | 254.3ºC |
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| Exact Mass | 285.13600 |
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| PSA | 61.72000 |
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| LogP | 2.86470 |
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| Vapour Pressure | 1.69E-10mmHg at 25°C |
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| Index of Refraction | 1.62 |
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| InChIKey | LVVKXRQZSRUVPY-OAHLLOKOSA-N |
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| SMILES | COc1cc2c(cc1O)C(Cc1ccc(O)cc1)NCC2 |
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Safety Information
Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| R-Coclaurin |
| (+)-1R-Cocluaurine |
| (+)-Coclaurine |
| (1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol |
| (+)-1(R)-Coclaurine |
| d-Coclaurine |
| (R)-Coclaurine |
