Introduction：Basic information about CAS 709-55-7|Etilefrin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Etilefrin |
|---|
| CAS Number | 709-55-7 | Molecular Weight | 181.23200 |
|---|
| Density | 1.127 g/cm3 | Boiling Point | 351.7ºC at 760 mmHg |
|---|
| Molecular Formula | C10H15NO2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 155.5ºC |
|---|
Names
| Name | 3-[2-(Ethylamino)-1-hydroxyethyl]phenol |
|---|
| Synonym | More Synonyms |
|---|
Etilefrin BiologicalActivity
| Description | Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist[2]. Etilefrine also is an AMPK activator[1]. Etilefrine can be used for the research of postural hypotension[3]. |
|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>AMPKResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorSignaling Pathways >>PI3K/Akt/mTOR >>AMPK |
|---|
| Target | AMPK |
|---|
| In Vivo | Etilefrine (0.1 mg/kg; i.v.) increases blood pressure (BP) and heart rate (HR), however, Etilefrine does not attenuate the decrease in BP induced by the tilt. Etilefrine also tends to increase cardiac output (CO)[3]. |
|---|
| References | [1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24. [2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5. [3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24. |
|---|
Chemical & Physical Properties
| Density | 1.127 g/cm3 |
|---|
| Boiling Point | 351.7ºC at 760 mmHg |
|---|
| Molecular Formula | C10H15NO2 |
|---|
| Molecular Weight | 181.23200 |
|---|
| Flash Point | 155.5ºC |
|---|
| Exact Mass | 181.11000 |
|---|
| PSA | 52.49000 |
|---|
| LogP | 1.42600 |
|---|
| Index of Refraction | 1.561 |
|---|
| InChIKey | SQVIAVUSQAWMKL-UHFFFAOYSA-N |
|---|
| SMILES | CCNCC(O)c1cccc(O)c1 |
|---|
Safety Information
Customs
| HS Code | 2922509090 |
|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
| ethylphenylarsine chloride |
| Aethyl-chlor-phenyl-arsin |
| Arsine,chloroethylphenyl-(6CI,7CI,8CI) |
| Arsinous chloride,ethylphenyl |
| ethylphenylephrine |
| Aethyl-phenyl-dithiocarbamidsaeure,Ammonium-Salz |
| ethyl(phenyl)arsinous chloride |
| Aethylphenylarsinchlorid |
| Aethylphenylarsenchlorid |
| ethyl-chloro-phenyl-arsine |
| ammonium N-ethyl-N-phenyldithiocarbamate |
| Chloroethylphenylarsine |
| (RS)-etilefrine |
| 2-ethylamino-1-(3-hydroxy-phenyl)-ethanol |
| ethyl-phenyl-dithiocarbamic acid,ammonium salt |
| Aethyl-phenyl-chlor-arsin |
| [3H]-(+/-)-Etilefrine |
| Ethylphenylchloroarsine |
